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Fig. 5 | Human Genomics

Fig. 5

From: Comprehensive assessments of germline deletion structural variants reveal the association between prognostic MUC4 and CEP72 deletions and immune response gene expression in colorectal cancer patients

Fig. 5

The correlation of DSVs and immune gene expression and prognostic stratification. a Heatmap of 57 DSV genes related to six functional immune expression categories. The ratio indicates the frequency of DSV genes related to immune expression. Only two DSV genes, STNG2 and LOC105376360, have p-adjusted values < 0.05. b Heatmap of 65 immune-related DSV genes and clinical outcomes. There are six functional immune categories: tumor characterization (green), lymphocyte regulation (purple), lymphocyte marker (orange), cytokine signaling (blue), checkpoint pathways (brown), and housekeeping (light blue). The value shown is the point-biserial correlation coefficient in the heatmap. There are poorer prognostic DSV genes correlated with the immune functional tumor characterization category and better prognostic DSV genes related to the immune functional lymphocyte regulation category. c RFS by Kaplan–Meier survival plots. The patients were stratified into G1 (orange) and G2 groups (blue) by prognostic deletions that have different clinical outcomes. The G2 group had better clinical outcome than the G1 group

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Human Genomics

ISSN: 1479-7364