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Fig. 1 | Human Genomics

Fig. 1

From: ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

Fig. 1

ACE, ACE2 and Collectrin chromosomal location and cellular localizations. The 3 type I transmembrane proteins ACE, ACE2, and collectrin located in the plasma membrane with activity differences. ACE acts as a dipeptidyl carboxypeptidase with 2 catalytic active sites for angiotensin I (Ang I) and angiotensin (1–9) (Ang (1–9)), whereas ACE2 acts as a monocarboxypeptidase possessing one active site that cleaves Ang I and angiotensin II (Ang II). However, collectrin lacks a catalytic activity in its extracellular domain. ACE2 and collectrin gene (CLTRN) are both mapped to chromosome Xp22.2 where ACE is located on chromosome 17q23.3

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