Table 1 ACE2 variants’ association in different diseases

rs2106809

-

Hypertension

Metabolic diseases

Diabetes mellitus type 2

[62, 71, 72]

rs2285666

-

Hypertension

Diabetes mellitus type 2

COVID-19

[63, 73, 74]

rs2074192

-

Hypertension

Diabetes mellitus type 2

Metabolic diseases

COVID-19

[64, 71, 75, 76]

rs879922

-

Hypertension

Diabetes mellitus type 2

Dyslipidemia

Stroke

[62, 74, 75, 77]

rs1978124

-

Hypertension

Diabetes mellitus type 2

Cardiovascular diseases

[74, 75]

rs4646155

-

Hypertension

Dyslipidemia

Cardiovascular diseases

[59, 74, 75]

rs4646156

-

Hypertension

Diabetes mellitus type 2

[74, 75]

rs4240157

-

Hypertension

Diabetes mellitus type 2

Cardiovascular diseases

[59, 74, 75]

rs233575

-

Hypertension

Diabetes mellitus type 2

Cardiovascular diseases

[59, 74, 75]

rs6632677

-

Cardiovascular diseases

[78]

rs4646176

-

Hypertension

[71, 73]

rs4830542

-

Hypertension

Dyslipidemia

[59, 74]

rs233575

-

Diabetes mellitus type 2

Dyslipidemia

[74, 75]

rs4646116

Likely-benign

COVID-19

[65, 67]

rs191860450

-

COVID-19

[65, 79]

rs784163894

-

COVID-19

[65]

rs183135788

-

COVID-19

[65]

rs149039346

-

COVID-19

[65, 80]

rs41303171

-

COVID-19

[65, 67]

rs147311723

-

COVID-19

[65, 80]