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Table 1 ACE2 variants’ association in different diseases

From: ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

ACE2 variant Clinical significance Related diseases Reference
rs2106809 - Hypertension
Metabolic diseases
Diabetes mellitus type 2
[62, 71, 72]
rs2285666 - Hypertension
Diabetes mellitus type 2
COVID-19
[63, 73, 74]
rs2074192 - Hypertension
Diabetes mellitus type 2
Metabolic diseases
COVID-19
[64, 71, 75, 76]
rs879922 - Hypertension
Diabetes mellitus type 2
Dyslipidemia
Stroke
[62, 74, 75, 77]
rs1978124 - Hypertension
Diabetes mellitus type 2
Cardiovascular diseases
[74, 75]
rs4646155 - Hypertension
Dyslipidemia
Cardiovascular diseases
[59, 74, 75]
rs4646156 - Hypertension
Diabetes mellitus type 2
[74, 75]
rs4240157 - Hypertension
Diabetes mellitus type 2
Cardiovascular diseases
[59, 74, 75]
rs233575 - Hypertension
Diabetes mellitus type 2
Cardiovascular diseases
[59, 74, 75]
rs6632677 - Cardiovascular diseases [78]
rs4646176 - Hypertension [71, 73]
rs4830542 - Hypertension
Dyslipidemia
[59, 74]
rs233575 - Diabetes mellitus type 2
Dyslipidemia
[74, 75]
rs4646116 Likely-benign COVID-19 [65, 67]
rs191860450 - COVID-19 [65, 79]
rs784163894 - COVID-19 [65]
rs183135788 - COVID-19 [65]
rs149039346 - COVID-19 [65, 80]
rs41303171 - COVID-19 [65, 67]
rs147311723 - COVID-19 [65, 80]