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Table 2 microRNAs targeting angiotensin-converting enzyme (ACE2)

From: ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

miRNA Effect on ACE2 Reference
miR-18a Inhibiting miR18a partially blocked ACE2 beneficial effect in hypoxia/reoxygenation endothelial cell model. [99]
miR-21 Ang II-induced miR-21 mediates the inhibition of ACE2 antifibrotic effect in lung fibroblasts. [100]
miR-29 Increased ACE2 expression in cardiac myocytes/fibroblasts during hypertrophic cardiomyopathy [101]
miR-98 and miR-223 Downregulation of miR-98 and miR-223 leads to reduced expression of ACE2 in bronchial stem cells during SARS infection. [102]
miR-125b High glucose-induced upregulation of miR-125b in renal tubular epithelial cells leads to reduced ACE2 expression during diabetic nephropathy. [95]
miR-483-3p AT1R-regulated expression of miR-483-3p regulates the expression of major RAS components, including ACE2. [94]
miR-421 Enhanced miR-421 expression in uremic patients downregulates ACE2 expression in the leukocytes during chronic kidney disease.
Increased expression of miR-421 in myofibroblasts also downregulates ACE2 expression in thrombosis.
[96, 103]
miR-143 Downregulated miR-143 induced by aerobic exercise training was accompanied by increased ACE2 expression in hypertensive rats. [104]
miR-4262 During acute lung injury, increased ACE2 expression suppresses miR-4262 leading to apoptotic Bcl2 upregulation and consequently inhibiting apoptosis. [98]
miR-9-5p and miR-218-5p Bioinformatic prediction algorithms identify miR-9-5p and miR-218-5p as regulators of SARS-CoV-2 through binding to 3′UTR region of ACE2. [105]