Convergent lines of evidence support BIN1 as a risk gene of Alzheimer’s disease

Table 2 Expression analysis of risk genes in AD cases and controls using AlzData database

Gene	Entorhinal cortex			Hippocampus			Temporal cortex			Frontal cortex
Gene	FC	P	FDR	FC	P	FDR	FC	P	FDR	FC	P	FDR
CR1	0.23	0.071	0.197	− 0.01	0.896	0.954	0.39	0.033	0.118	− 0.04	0.655	0.906
BIN1	− 0.12	0.265	0.452	− 0.26	0.002	0.028	− 0.09	0.458	0.67	0.11	0.13	0.268
HLA-DRA	0.46	0.042	0.142	NA	NA	NA	NA	NA	NA	NA	NA	NA

We investigated whether the identified risk genes are differentially expressed in AD patients compared to controls, using a comprehensive database AlzData (http://www.alzdata.org/). FC fold change, FDR false discovery rate, NA not available

ISSN: 1479-7364