Fig. 3

Protein–protein interactions (PPI) network, module analysis, and hub gene identification. The most significant modules were screened out by using the CytoHubba plug-in. Nodes represent gene; lines represent interactions between gene-encoded protein. a Construction of PPI networks. Direct molecular interaction network between novel coronavirus differently regulated genes supported by experiments, encoded protein; b PPI network of the top 12 hub genes (the redder the color, the more important it is)