Table 2 Upregulated genes and downregulated genes that meet the screening criteria

Upregulated

KPNA7,RAB32,TMEM132A,CD7,A1BG-AS1,CDH2,ANGPTL4,BAMBI,ULBP1,DDX58,CYP8B1,CSTB,PNMA2,NEFM,SOCS1,NCF2,LINC00152,SOD2,THBS1,CYR61,HCG4B,IFITM2,COL6A2,TAGLN,TGFBR3L,TINAGL1,RASGRP3,TNFAIP2,ST6GALNAC5,GOLT1A,NALCN,TMIE,ABCA12,LRRC3,HMGA2,RELT,MTNR1A,CAPN14,ELOVL3,CEACAM19,GRAP,DGKI,NLRC4,BST2,DDIT4L,GBP4,HGD,ISG20,ZBED2,FEZ1,TMEM92,PRSS30P,FTH1,C10orf55,SIRPB2,MTHFD2,ARL4C,SUSD2,ITGB2,THY1,FUOM,RAB3B,KIF12,CBS,CPXM2,IFITM3,GAS6,LOC644936,MMD,LCP1,CTGF,FNDC4,EGOT,NRIP3,GFI1,WNT11,ARL9,ZC3H12A,MOGAT2,RCN3,IL2RG,MPV17L,TMEM106A,TMEM163,ADM2,LINC01215,FAP,SLC2A6,KRT7,HSD17B14,GREB1L,UCHL1,ALOXE3,NCF1,S100A12,RAC2,CYGB,ITGA5,NDP,PTAFR,NWD2,RFTN1,FAM155B,ALOX15B,REN,BATF2,PNMAL2,CPNE4,MEOX1,IRF7,ZNF876P,SLC34A2,HSH2D,GLDC,TNFSF14,SLC26A9,HDAC9,NKILA,RASGRF2,BIRC3,EGF,TUBB3,DPYSL4,DDX60,SLC8A2,FSTL3,ADAMTS1,SERPIND1,GSTM3,NFKBIA,TREM1,ADAM8,SCG5,SLC15A3,PARM1,DDO,RHEBL1,TSPAN2,CHD5,LHX5,FBLN7,PDCD1LG2,DUSP5,UCA1,C3,ARSF,BICC1,HIST1H1E,XKR9,PDZK1IP1,SAMD14,BCL2L15,IL24,GRIP2,FZD9,1-Dec,FGF2,MT1L,NOTCH4,IL7,KYNU,RBM24,TMPRSS2,TNIP1,THEMIS2,RENBP,FAM181B,VNN3,LOC101927865,LOC101927571,EDN1,RASD2,USP18,TNFAIP3,CYB5R2,CPA6,MAPK8IP2,SLC39A8,TYMP,DYSF,IER3,XAF1,CSF1R,OAS3,CAMK1G,CD83,IL15,LOC100130476,TRIM36,HKDC1,TAGLN3,RHCG,PDGFRL,PTP4A3,CILP2,ITPKA,LOC100505622,FABP6,PRRX2,CD200,BVES,TRIB3,KLHDC7B,IFI35,CST6,LOC102724279,RNU6-2,LAPTM5,SLC13A5,MFI2,BMP2,KRTAP2-3,KLK8,CCRL2,DHRS2,CD79A,SRGN,KLK9,PTPRH,ZFP42,CXCL6,ZG16B,WFDC5,HSD17B2,HBEGF,MUC3A,SEMA7A,PTGS2,PI3,MAFF,ADAMTS4,MEI1,GRB14,KMO,TMEM171,C6orf223,LCN2,HLA-B,KCNG1,LOC102467080,ATP6V0D2,IFI44,RPSAP52,GAS6-AS2,SERPINB7,OAS2,GPR176,TFPI2,CD70,GGT1,OTOP3,SHISA2,FN1,CTSE,DUOX2,LEMD1,NTM,KCCAT211,ANXA6,MIR146A,SH3RF3,RNASE1,PRSS22,LOC101929705,NODAL,LAMC2,IFIT2,ADAM19,INSC,C3orf70,IGFN1,DAAM2,CXCL1,NOG,HERC6,BPGM,HHIP,FAM169B,NEURL3,AMTN,IL6,PIWIL2,NCF1C,TBXAS1,FPR1,AANAT,PLAUR,CFB,TAF7L,BAG6,CDA,ASPHD1,LGALS2,TRABD2A,ICAM1,CCL2,ESM1,VNN1,4-Mar,KLK6,SLC7A7,HLA-F,NT5E,IL7R,POU2F2,POPDC3,C10orf10,SLC5A1,NOXO1,SELL,SSC4D,ZNF114,STC2,ART3,ALDOB,SAA2,PLAU,IL36G,BEST1,SPRR2D,FAM205A,PARVB,MUC13,SH2D2A,EPSTI1,LIF,TNFRSF9,NES,SAA4,ADRA1B,AWAT2,RASD1,ANXA2P3,ADAMTS9,MMP7,XDH,IL4I1,RAB42,PSG9,LAMP3,ANKRD1,HSD11B1,RND1,TNIP3,NOX1,ADAMTS6,UBD,IL1R2,MPZ,WNT7A,SV2B,IL32,MYCT1,MT2A,BCL2A1,DIO3,IDO2,TRPV2,NTNG1,LOC102723649,CXCL9,SNAI1,SYNGR3,IDO1,OLFM1,KLK5,KCNN3,RNASE7,C15orf48,SPRR2C,APOBEC3A,ROBO4,HEPHL1,SYNDIG1,HMGN2P46,SAA1,CUX2,IFITM1,SLC5A8,B4GALNT2,LINC00880,COL22A1,GFPT2,L1CAM,GDF15,CXCL8,MSC-AS1,IL19,PLA2G4C,TFF1,IFIT3,TRHDE,CXCL2,ATRNL1,CHAC1,G0S2,GBP5,CLLU1OS,SELP,C8orf4,MMP8,ZNF385C,MYH16,FOLR3,PDE4B,MRGPRX3,MMP9,SLC7A2,C19orf38,GRIN2A,MCHR1,PITX3,IFIT1,IL12RB1,COL13A1,IL17C,NCF1B,IL1A,CEACAM7,SMOC1,CCL20,SERPINA3,CD69,IFI27,ALPL,EPS8L3,OASL,LOC100126784,BEAN1,AMZ1,SPRR2A,SLC5A5,PDGFB,SPRR2E,HERC5,EBI3,CDH19,CYP27A1,DUOXA2,LOC101929427,SLC26A4-AS1,SERPINE1,MX1,ISG15,CXCL3,INHBA,HS3ST2,C4orf26,DSCAM,MSC,CD177,KISS1,SLCO4A1,C1QTNF1,CPXM1,MICA,IL17REL,LSAMP,IFI6,LEFTY1,IFI44L,SERPINA5,CXCL10,CXCL5,SPRR2F,S100A7A,GAL,KCNK3,VPS52,PPP1R10,GCGR,S100A7,CCL5,IL1B,IL23A,CMPK2,SLC26A4,MX2,CXCL11,DEFB4A,TNFRSF1B,RSAD2,ZBP1,ENPP6,CDH5,CSF3,CSF2,LSM2,FDCSP,PRSS1

Downregulated

KRT1,DIO2,DSG1,GTF2H4,RPS17,WDR46,DHX16,GRIK3,ABCF1,LUZP2,CYP4F22,UGT1A7,SPINK7,PDZRN4,ANGPTL2,KCNJ16,COL3A1,KRT4,LOC100506834,SRD5A2,CADM2,KCNH2,CRNN,AQP6,HMGCS2,GLI1,VIPR1-AS1,LINC01583,SPARCL1,SLC6A4,KRTDAP,PTPRT,FRMPD3,PTPRQ,TSLP,NHSL2,ADH1A,CEMIP,ELN,FLG2,KRT16P2,POU3F1,NBPF11,TNNT2,ELAVL2,EYS,NGB,RIMKLA,CRISP3,CD99,PLXDC1,EPB41L3,HMCN1,RPTN,APCDD1,AJAP1,IGFBP5,MAP7D2,SDR9C7,SNORD59B,PPP1R42,FAT3,PSAPL1,PRKCB,SLURP1,STEAP3-AS1,KRT15,EVPLL,BGN,ANPEP,POSTN,MPPED2,SMIM17,SLC10A5,EPHA3,SHISA9,C1orf168,SLC1A3,ASXL3,KRT13,RBM20,ANXA10,AADAC,FGF14-AS2,SBSN,MANEA-AS1,CACNA1D,PPP1R16B,RERG,IGFL1,KRT10,LOC101927023,CCDC136,DCLK1,ELFN1,CCDC73,AR,RTN4RL1,LOC730101,HOXA2,HYDIN2,IGFL2,TNNI2,HTR2B,GATA3-AS1,GLI2,SYNPO2,GRM4,HLF,FAM153A,KANTR,SLC24A3,GPR20,MSI1,DAPL1,FAM46C,CXCL14,PCDH18,CLDN8,GPC3,MESP1,CCDC3,DNAH6,SLC47A2,DNASE1L3,COL21A1,TPTE2P1,LINC01121,CYP4Z2P,RTCA-AS1,UMODL1,ANKH,P2RY1,GSTA2,RDH12,DMRT3,ZNF157,CHRNE,CNR1,LY6H,KRT16P3,EPGN,MIR4523,FABP4,TMPRSS11B,GUSBP9,LINC01116,EPHA7,C14orf132,MCM10,H19,FOXP2,APOBEC2,TP73,SMAD5-AS1,MIR4653,SPOCK2,SAMD5,SOSTDC1,MTUS2,TAS2R14,TMEM200A,SNX31,BEND5,DNAJC22,CLIC5,CYP2C8,IL2RB,C2orf73,SYT13,NKAPP1,CILP,TGM3,LOC200772,ARHGEF33,OR7E47P,FAM25A,COLCA1,MAP2K6,TMEM220-AS1,KRT6C,NUDT10,CXCL13,PAK7,PDE6A,EPPIN,HOPX,MFAP4,RNF222,CYP4B1,POU2AF1,SCN2B,MAP6,SEMA3G,PIK3C2G,LOC101929378,ECM2,MBNL1-AS1,LOC101927318,KIT,IL12RB2,SCN9A,PDE3B,KCNH4,SLAMF8,FOXI1,GOLGA8T,C1orf101,LINC01206,MIR27B,CLSTN2,SESN3,HERC2P3,SEMA5A,CLEC18A,ADGRL3,EDN2,FAIM2,CH25H,NLGN4X,ZNF233,DUSP9,DLK2,CTD-2201I18.1,UGT2A1,CDCA7,MIR6753,NEIL3,KNDC1,ERICH3,SEPP1,SOD3,ADGRF5,LINC01094,LOC100507283,MIR4517,GOLGA6L3,KIAA2022,TINCR,LOC100506127,HS3ST6,FOXN1,LOC100286922,LINC01132,ITGA10,PAQR5,RGAG4,GPR63,CPA4,TGFBR3,SPON2,PNPLA1,LOC441178,ATP8B4,EML6,CYP7B1,WSCD2,ACVR2B-AS1,AQP5,RGS22,LOC100129203,SKIDA1,PI16,LOC105373383,ENDOU,UGT2B28,METTL7A,SPTSSB,FKBP5,TET1,FETUB,ARHGAP28,CKAP2L,SNORD31,MPL,E2F2,SALRNA1,BMS1P5,PDGFD,ANXA2R,SNHG21,MIR99AHG,LOC100130093,EXO1,CARD18,UNC5C,BCL11B,DNAH9,CDHR3,C2orf71,CD36,SYT8,IGSF11,OPCML,INO80B,PKMYT1,SPOCK3,USP6,ADH7,MIR200B,LOC100128076,SLC25A34,HRASLS,DMRT2,SEPT5-GP1BB,CENPA,CYP4F3,LOC101929567,ECT2L,BAALC,CYP4F29P,LMO2,LEF1,DEPTOR,HSD17B13,FAM216B,ARHGAP11B,ALS2CR12,ADAD2,AGBL2,CARNS1,KIF11,F5,RGMA,PDE7B,CYP2C9,PALM,UGT2B17,FIBIN,COL5A3,KLHL31,VIPR1,CCDC62,HEY2,SUSD5,LOC100130417,LINC00683,SNHG19,MKI67,IL5RA,GAS1,ADAMTS5,MIR23B,TUB,MROH9,DEPDC7,OR7E91P,JMJD1C-AS1,TDRD1,AQP2,TEN1-CDK3,MIR186,COMP,ADAM23,LGI3,TOP2A,AADACP1,NOS2,SAXO2,ZRANB2-AS1,HEPACAM2,C1orf87,PCSK1,WNT3A,FLRT1,LMNB1,SEMA6D,HECW2,TREX2,LOC100507462,FOXD2,MKNK1-AS1,NWD1,PTGS1,TRPC6,GSTA1,GATA3,RGS4,IL6R,HSPB3,ARL14,FAM19A2,NDC80,CCR7,ACSS3,SPAG8,ITM2A,ZNF853,LOC100131655,GPR78,IL33,CYP4F12,EPHA4,BMP7,IGSF10,CFAP74,DTL,LOC339260,CCNE2,FAM131B,FGFR1,KCNJ5,AQP1,KIF26A,CHGB,TNNT3,C5,CUBN,NFIA,TFF3,PROC,ARHGEF26,TDRD6,CEP55,MBNL3,IL16,LOC100507006,KCNQ5,ZNF367,SNORA63,NPNT,CHRNA7,LINC01410,INHBB,KLLN,PLA2G4F,NCAPG,EGFL6,LGALS4,COL2A1,FZD1,MERTK,DNAAF1,LINC00664,FAM20A,DACT2,KC6,ENTPD8,UCP3,CASC5,EPHA10,RAET1E,ZNF608,AMH,LOC100129917,MYO3B,FAM181A-AS1,KCNAB3,VWA3B,CFAP43,SUSD4,WDR76,GATM,IP6K3,TCF4,FAM65B,LINC01481,DNAH3,KIF18B,POLQ,DLGAP5,STAG3L1,ZFHX4,ABLIM2,ABCA9,LHX6,ITGB7,LOC101928020,PDK4,CYP2W1,C6orf118,FILIP1,LOC100130705,LRGUK,PRUNE2,DTHD1