Table 3 The collection of significantly enricher GO pathways (top 10 according to P value)

BP

GO:0060326

Cell chemotaxis

51

1.77E−17

IL1B/CCL20/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/DEFB4A/CXCL1/IL23A/PDGFB/IL36G/SAA2/SAA1/CXCL11/RAC2/GAS6/CXCL6/HBEGF/CCL5/EDN1/ADAM8/SEMA5A/CXCL14/ITGB2/S100A7/THBS1/CXCL13/DYSF/IL6R/PDE4B/CH25H/IL16/KIT/EDN2/CXCL9/S100A12/CCL2/SAA4/TNFSF14/C5/FGFR1/LEF1/FGF2/CCRL2/PDGFD/CCR7/IL6/CYP7B1/SLAMF8

BP

GO:0030595

Leukocyte chemotaxis

41

1.21E−15

IL1B/CCL20/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/CXCL1/IL23A/PDGFB/IL36G/SAA1/CXCL11/RAC2/GAS6/CXCL6/CCL5/EDN1/ADAM8/CXCL14/ITGB2/S100A7/THBS1/CXCL13/DYSF/IL6R/PDE4B/CH25H/IL16/KIT/EDN2/CXCL9/S100A12/CCL2/TNFSF14/C5/CCR7/IL6/CYP7B1/SLAMF8

BP

GO:0097529

Myeloid leukocyte migration

39

3.68E−15

IL1B/CCL20/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/CXCL1/IL23A/PDGFB/IL36G/SAA1/CXCL11/RAC2/CXCL6/CCL5/EDN1/ADAM8/CD177/ITGB2/S100A7/THBS1/CXCL13/DYSF/IL6R/PDE4B/KIT/EDN2/CXCL9/S100A12/CCL2/C5/CD99/PDGFD/CCR7/IL6/CD200/SLAMF8

BP

GO:1990266

Neutrophil migration

29

6.55E−15

IL1B/CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/IL23A/IL36G/SAA1/CXCL11/RAC2/CXCL6/CCL5/EDN1/ADAM8/CD177/ITGB2/CXCL13/DYSF/PDE4B/EDN2/CXCL9/S100A12/CCL2/CD99/CCR7/SLAMF8

BP

GO:0097530

Granulocyte migration

31

2.10E−14

IL1B/CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/IL23A/IL36G/SAA1/CXCL11/RAC2/CXCL6/CCL5/EDN1/ADAM8/CD177/ITGB2/S100A7/THBS1/CXCL13/DYSF/PDE4B/EDN2/CXCL9/S100A12/CCL2/CD99/CCR7/SLAMF8

BP

GO:0032496

Response to lipopolysaccharide

48

4.74E−14

IL1B/CSF3/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/ALPL/CXCL1/IDO1/TNFAIP3/IL36G/CXCL11/CXCL6/ICAM1/NFKBIA/CMPK2/PTGS2/SPON2/LCN2/ZC3H12A/CCL5/PTAFR/CSF2/GGT1/TNIP3/EDN1/ANKRD1/S100A7/CXCL13/PDCD1LG2/NOS2/PDE4B/KMO/CD36/TNFRSF1B/IL12RB2/CXCL9/CCL2/SELP/MIR146A/GFI1/CCR7/IL6/REN/CNR1/IL24

BP

GO:0071222

Cellular response to lipopolysaccharide

37

4.80E−14

IL1B/CSF3/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/CXCL1/TNFAIP3/IL36G/CXCL11/CXCL6/ICAM1/NFKBIA/CMPK2/SPON2/LCN2/ZC3H12A/CCL5/PTAFR/CSF2/TNIP3/ANKRD1/CXCL13/PDCD1LG2/NOS2/PDE4B/KMO/CD36/TNFRSF1B/CXCL9/CCL2/MIR146A/GFI1/IL6/IL24

BP

GO:0071219

Cellular response to molecule of bacterial origin

37

1.42E−13

IL1B/CSF3/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/CXCL1/TNFAIP3/IL36G/CXCL11/CXCL6/ICAM1/NFKBIA/CMPK2/SPON2/LCN2/ZC3H12A/CCL5/PTAFR/CSF2/TNIP3/ANKRD1/CXCL13/PDCD1LG2/NOS2/PDE4B/KMO/CD36/TNFRSF1B/CXCL9/CCL2/MIR146A/GFI1/IL6/IL24

BP

GO:0050900

Leukocyte migration

60

1.91E−13

IL1B/CCL20/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/CXCL1/IL23A/PDGFB/IL36G/L1CAM/SAA1/CXCL11/RAC2/ITGA5/GAS6/CXCL6/ICAM1/CCL5/PTAFR/EDN1/SLC7A7/ADAM8/CD177/CXCL14/GATA3/FN1/IL33/ITGB2/S100A7/SELL/THBS1/CXCL13/DYSF/IL6R/PDE4B/CH25H/IL16/KIT/EDN2/CXCL9/ITGB7/S100A12/CCL2/MERTK/TNFSF14/THY1/C5/GRB14/TREM1/SELP/CD99/PDGFD/CCR7/IL6/CD200/CYP7B1/SLAMF8

BP

GO:0002237

Response to molecule of bacterial origin

48

2.08E−13

IL1B/CSF3/CXCL8/CXCL5/SERPINE1/CXCL2/CXCL3/CXCL10/ALPL/CXCL1/IDO1/TNFAIP3/IL36G/CXCL11/CXCL6/ICAM1/NFKBIA/CMPK2/PTGS2/SPON2/LCN2/ZC3H12A/CCL5/PTAFR/CSF2/GGT1/TNIP3/EDN1/ANKRD1/S100A7/CXCL13/PDCD1LG2/NOS2/PDE4B/KMO/CD36/TNFRSF1B/IL12RB2/CXCL9/CCL2/SELP/MIR146A/GFI1/CCR7/IL6/REN/CNR1/IL24

CC

GO:0062023

Collagen-containing extracellular matrix

52

2.39E−13

SERPINE1/ADAM19/HMCN1/SERPINA3/KRT1/GDF15/PDGFB/PRSS1/L1CAM/COL3A1/MMP9/ICAM1/SEMA7A/CSTB/LAMC2/GPC3/NPNT/SMOC1/TINAGL1/ANXA6/FN1/ELN/BMP7/COL21A1/ANGPTL2/EYS/COMP/ADAMTS1/EGFL6/SERPINA5/S100A7/CDH2/POSTN/THBS1/IL7/AMTN/CILP/COL5A3/COL13A1/ADAMTS5/BGN/COL6A2/SPARCL1/ADAMTS9/MMP8/MFAP4/SOD3/ADAMTS4/NDP/ECM2/LGALS4/COL2A1

CC

GO:0005788

Endoplasmic reticulum lumen

37

4.67E−09

WNT7A/PLAUR/COL22A1/IL23A/PDGFB/IGFBP5/COL3A1/GAS6/STC2/C3/PTGS2/FSTL3/TMEM132A/EBI3/GPC3/EDN1/FN1/COL21A1/PROC/CDH2/THBS1/AMTN/COL5A3/COL13A1/RCN3/ADAMTS5/COL6A2/SPARCL1/F5/ARSF/WNT3A/CYP2W1/PDGFD/CHGB/SERPIND1/IL6/COL2A1

CC

GO:0031225

Anchored component of membrane

25

2.69E−08

CEACAM7/ALPL/PLAUR/NT5E/PRSS22/SEMA7A/NTM/VNN1/GPC3/CD177/VNN3/RGMA/OPCML/BST2/ENPP6/FOLR3/NTNG1/GAS1/THY1/RAB3B/LSAMP/ART3/ULBP1/RTN4RL1/LY6H

CC

GO:0009897

External side of plasma membrane

41

3.80E−08

CXCL10/ITGA5/ICAM1/SEMA7A/EBI3/HLA-B/SSC4D/CD83/IL12RB1/SERPINA5/ITGB2/KCNJ5/CDH5/THBS1/IL6R/RAET1E/IL7R/HLA-F/PDCD1LG2/TNFRSF9/CD69/CD36/KIT/TGFBR3/IL12RB2/CXCL9/FOLR3/ANPEP/MICA/IL2RG/IL2RB/THY1/CUBN/SELP/IL5RA/ULBP1/RTN4RL1/CCRL2/CD79A/UMODL1/CCR7

CC

GO:0043020

NADPH oxidase complex

7

8.82E−07

DUOX2/NCF2/NOXO1/NOX1/NCF1B/NCF1/NCF1C

CC

GO:0001533

Cornified envelope

12

1.07E−05

SPRR2F/SPRR2D/KRT1/KRT10/SPRR2A/CST6/DSG1/PI3/SPRR2E/FLG2/RPTN/EVPLL

CC

GO:0070820

Tertiary granule

19

4.14E−05

CXCL1/PLAU/MMP9/CSTB/DSG1/PTAFR/CDA/ADAM8/CD177/FTH1/METTL7A/ITGB2/FLG2/FOLR3/FRMPD3/CRISP3/MMP8/ATP8B4/FPR1

CC

GO:1904724

Tertiary granule lumen

10

6.64E−05

CXCL1/MMP9/CSTB/CDA/FTH1/METTL7A/FLG2/FOLR3/CRISP3/MMP8

CC

GO:0045177

Apical part of cell

32

0.000111784

CEACAM7/SLC26A4/DUOXA2/SLC5A1/RHCG/DUOX2/KISS1/DSG1/PTPRH/AQP5/SLC34A2/FN1/P2RY1/AJAP1/SLC26A9/CDH2/SLC5A8/MUC13/BST2/CLIC5/IL6R/CYP4F12/AQP6/CD36/FAP/THY1/ATP6V0D2/CUBN/AQP2/ADGRF5/AQP1/REN

CC

GO:0016324

Apical plasma membrane

28

0.000117339

CEACAM7/SLC26A4/SLC5A1/RHCG/DUOX2/KISS1/DSG1/PTPRH/AQP5/SLC34A2/FN1/P2RY1/AJAP1/SLC26A9/CDH2/SLC5A8/MUC13/BST2/CLIC5/IL6R/CYP4F12/AQP6/CD36/THY1/ATP6V0D2/CUBN/AQP2/AQP1

MF

GO:0048018

Receptor ligand activity

73

2.69E−21

IL1B/IL1A/CCL20/CSF3/CXCL8/CXCL5/CXCL2/TSLP/CXCL3/INHBA/CXCL10/LIF/DEFB4A/CXCL1/WNT7A/GDF15/IL23A/PDGFB/IL36G/SAA2/TYMP/SAA1/CXCL11/GAS6/CXCL6/SEMA7A/STC2/BMP2/HBEGF/CCL5/IL32/EBI3/CSF2/EDN1/SEMA5A/CXCL14/IL19/BMP7/IL33/ADM2/IL17C/CXCL13/IL6R/EGF/TFF1/IL15/IL7/IL16/SEMA6D/EDN2/GAL/CXCL9/CCL2/EPGN/CD70/SAA4/SLURP1/LEFTY1/TNFSF14/SEMA3G/INHBB/C5/FGF2/WNT3A/PDGFD/CHGB/EPHA7/NDP/IL6/ENDOU/AMH/IL24/NODAL

MF

GO:0005125

Cytokine activity

47

3.18E−20

IL1B/IL1A/CCL20/CSF3/CXCL8/CXCL5/CXCL2/TSLP/CXCL3/INHBA/CXCL10/LIF/CXCL1/WNT7A/GDF15/IL23A/IL36G/CXCL11/CXCL6/BMP2/CCL5/IL32/EBI3/CSF2/EDN1/CXCL14/IL19/BMP7/IL33/IL17C/CXCL13/IL15/IL7/IL16/CXCL9/CCL2/CD70/SLURP1/LEFTY1/TNFSF14/INHBB/C5/FGF2/NDP/IL6/IL24/NODAL

MF

GO:0005126

Cytokine receptor binding

46

8.30E−15

IL1B/IL1A/CCL20/CSF3/CXCL8/CXCL5/CXCL2/TSLP/CXCL3/INHBA/CXCL10/LIF/DEFB4A/CXCL1/GDF15/IL23A/IL36G/CXCL11/ITGA5/CXCL6/BMP2/CCL5/EBI3/CSF2/CXCL14/GATA3/BMP7/IL12RB1/CDH5/BAMBI/CXCL13/IL6R/IL15/IL7/TGFBR3/CXCL9/CCL2/CD70/LEFTY1/TNFSF14/INHBB/C5/CCRL2/IL6/AMH/NODAL

MF

GO:0005539

Glycosaminoglycan binding

36

1.43E−11

CXCL10/MMP7/SAA1/CXCL11/CXCL6/HBEGF/LAMC2/RNASE7/CEMIP/SEMA5A/SPOCK3/ANXA6/FN1/BMP7/COMP/ADAMTS1/SERPINA5/SELL/POSTN/THBS1/CXCL13/COL5A3/COL13A1/TGFBR3/ADAMTS5/BGN/FGFR1/SPOCK2/SELP/FGF2/RTN4RL1/FBLN7/SOD3/ECM2/SERPIND1/SUSD5

MF

GO:0008201

Heparin binding

28

7.83E−10

CXCL10/MMP7/SAA1/CXCL11/CXCL6/HBEGF/LAMC2/FN1/BMP7/COMP/ADAMTS1/SERPINA5/SELL/POSTN/THBS1/CXCL13/COL5A3/COL13A1/TGFBR3/ADAMTS5/FGFR1/SELP/FGF2/RTN4RL1/FBLN7/SOD3/ECM2/SERPIND1

MF

GO:0008009

Chemokine activity

15

1.11E−09

CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/CXCL11/CXCL6/CCL5/CXCL14/CXCL13/CXCL9/CCL2/C5

MF

GO:0042379

Chemokine receptor binding

17

1.71E−09

CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/DEFB4A/CXCL1/CXCL11/CXCL6/CCL5/CXCL14/CXCL13/CXCL9/CCL2/C5/CCRL2

MF

GO:0030414

Peptidase inhibitor activity

27

1.83E−08

SERPINE1/SERPINA3/GAS6/CST6/C3/SPINK7/CSTB/PI3/TFPI2/GPC3/SPOCK3/SERPINB7/BIRC3/WFDC5/SERPINA5/BST2/FETUB/TNFSF14/RENBP/C5/LEF1/SPOCK2/UMODL1/CARD18/SERPIND1/PI16/EPPIN

MF

GO:1901681

Sulfur compound binding

32

3.47E−08

CXCL10/MMP7/SAA1/CXCL11/CXCL6/HBEGF/LAMC2/SEMA5A/ANXA6/GSTM3/FN1/BMP7/COMP/ADAMTS1/SERPINA5/SELL/POSTN/CBS/THBS1/CXCL13/COL5A3/COL13A1/TGFBR3/ADAMTS5/FGFR1/SELP/FGF2/RTN4RL1/FBLN7/SOD3/ECM2/SERPIND1

MF

GO:0005178

Integrin binding

22

4.57E−08

IL1B/ISG15/COL3A1/ITGA5/ICAM1/SEMA7A/NPNT/CD177/FN1/COMP/EGFL6/ITGB2/THBS1/ITGB7/ADAMTS5/FAP/THY1/LCP1/ESM1/FGF2/ECM2/ADAM23