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Table 4 Eleven most significantly enriched KEGG pathways

From: Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids

ID Description Count P value P. adjust Gene ID
hsa04060 Cytokine-cytokine receptor interaction 54 3.59E−20 3.41E−18 IL1B/IL1A/CCL20/CSF3/CXCL8/CXCL5/CXCL2/TSLP/CXCL3/INHBA/CXCL10/LIF/CXCL1/GDF15/IL23A/IL36G/CXCL11/CXCL6/BMP2/CCL5/IL32/CSF2/CXCL14/IL19/BMP7/IL33/RELT/IL12RB1/IL17C/CXCL13/IL6R/IL7R/TNFRSF9/IL15/IL7/IL16/TNFRSF1B/IL12RB2/CXCL9/CSF1R/CCL2/CD70/IL2RG/IL2RB/TNFSF14/INHBB/IL1R2/IL5RA/CCR7/IL6/AMH/IL24/NODAL/MPL
hsa04061 Viral protein interaction with cytokine and cytokine receptor 24 6.71E−12 3.19E−10 CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/CXCL11/CXCL6/CCL5/CXCL14/IL19/CXCL13/IL6R/TNFRSF1B/CXCL9/CSF1R/CCL2/IL2RG/IL2RB/TNFSF14/CCR7/IL6/IL24
hsa04064 NF-kappa B signaling pathway 15 5.89E−05 0.00186373 IL1B/CXCL8/CXCL2/CXCL3/CXCL1/PLAU/TNFAIP3/BCL2A1/ICAM1/NFKBIA/PTGS2/BIRC3/PRKCB/DDX58/TNFSF14
hsa00982 Drug metabolism—cytochrome P450 11 0.000306597 0.007281679 ADH7/GSTM3/GSTA2/GSTA1/CYP2C9/UGT1A7/ADH1A/UGT2A1/CYP2C8/UGT2B28/UGT2B17
hsa00590 Arachidonic acid metabolism 10 0.000471477 0.008885837 PTGS2/GGT1/ALOX15B/PLA2G4C/CYP4F3/PLA2G4F/PTGS1/TBXAS1/CYP2C9/CYP2C8
hsa00980 Metabolism of xenobiotics by cytochrome P450 11 0.000561211 0.008885837 ADH7/GSTM3/GSTA2/GSTA1/CYP2C9/UGT1A7/ADH1A/HSD11B1/UGT2A1/UGT2B28/UGT2B17
hsa04062 Chemokine signaling pathway 19 0.000840976 0.010436507 CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/CXCL11/RAC2/CXCL6/NFKBIA/CCL5/CXCL14/PRKCB/CXCL13/CXCL9/CCL2/NCF1/CCR7
hsa00830 Retinol metabolism 10 0.000878864 0.010436507 ADH7/AWAT2/CYP2C9/UGT1A7/RDH12/ADH1A/UGT2A1/CYP2C8/UGT2B28/UGT2B17
hsa00983 Drug metabolism—other enzymes 10 0.002812844 0.029691134 XDH/TYMP/CDA/GSTM3/GSTA2/GSTA1/UGT1A7/UGT2A1/UGT2B28/UGT2B17
hsa00140 Steroid hormone biosynthesis 8 0.005895127 0.053494911 HSD17B2/SRD5A2/UGT1A7/HSD11B1/UGT2A1/UGT2B28/UGT2B17/CYP7B1
hsa00120 Primary bile acid biosynthesis 4 0.006194148 0.053494911 CYP27A1/CH25H/CYP7B1/CYP8B1