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Table 4 Eleven most significantly enriched KEGG pathways

From: Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids

ID

Description

Count

P value

P. adjust

Gene ID

hsa04060

Cytokine-cytokine receptor interaction

54

3.59E−20

3.41E−18

IL1B/IL1A/CCL20/CSF3/CXCL8/CXCL5/CXCL2/TSLP/CXCL3/INHBA/CXCL10/LIF/CXCL1/GDF15/IL23A/IL36G/CXCL11/CXCL6/BMP2/CCL5/IL32/CSF2/CXCL14/IL19/BMP7/IL33/RELT/IL12RB1/IL17C/CXCL13/IL6R/IL7R/TNFRSF9/IL15/IL7/IL16/TNFRSF1B/IL12RB2/CXCL9/CSF1R/CCL2/CD70/IL2RG/IL2RB/TNFSF14/INHBB/IL1R2/IL5RA/CCR7/IL6/AMH/IL24/NODAL/MPL

hsa04061

Viral protein interaction with cytokine and cytokine receptor

24

6.71E−12

3.19E−10

CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/CXCL11/CXCL6/CCL5/CXCL14/IL19/CXCL13/IL6R/TNFRSF1B/CXCL9/CSF1R/CCL2/IL2RG/IL2RB/TNFSF14/CCR7/IL6/IL24

hsa04064

NF-kappa B signaling pathway

15

5.89E−05

0.00186373

IL1B/CXCL8/CXCL2/CXCL3/CXCL1/PLAU/TNFAIP3/BCL2A1/ICAM1/NFKBIA/PTGS2/BIRC3/PRKCB/DDX58/TNFSF14

hsa00982

Drug metabolism—cytochrome P450

11

0.000306597

0.007281679

ADH7/GSTM3/GSTA2/GSTA1/CYP2C9/UGT1A7/ADH1A/UGT2A1/CYP2C8/UGT2B28/UGT2B17

hsa00590

Arachidonic acid metabolism

10

0.000471477

0.008885837

PTGS2/GGT1/ALOX15B/PLA2G4C/CYP4F3/PLA2G4F/PTGS1/TBXAS1/CYP2C9/CYP2C8

hsa00980

Metabolism of xenobiotics by cytochrome P450

11

0.000561211

0.008885837

ADH7/GSTM3/GSTA2/GSTA1/CYP2C9/UGT1A7/ADH1A/HSD11B1/UGT2A1/UGT2B28/UGT2B17

hsa04062

Chemokine signaling pathway

19

0.000840976

0.010436507

CCL20/CXCL8/CXCL5/CXCL2/CXCL3/CXCL10/CXCL1/CXCL11/RAC2/CXCL6/NFKBIA/CCL5/CXCL14/PRKCB/CXCL13/CXCL9/CCL2/NCF1/CCR7

hsa00830

Retinol metabolism

10

0.000878864

0.010436507

ADH7/AWAT2/CYP2C9/UGT1A7/RDH12/ADH1A/UGT2A1/CYP2C8/UGT2B28/UGT2B17

hsa00983

Drug metabolism—other enzymes

10

0.002812844

0.029691134

XDH/TYMP/CDA/GSTM3/GSTA2/GSTA1/UGT1A7/UGT2A1/UGT2B28/UGT2B17

hsa00140

Steroid hormone biosynthesis

8

0.005895127

0.053494911

HSD17B2/SRD5A2/UGT1A7/HSD11B1/UGT2A1/UGT2B28/UGT2B17/CYP7B1

hsa00120

Primary bile acid biosynthesis

4

0.006194148

0.053494911

CYP27A1/CH25H/CYP7B1/CYP8B1