Fig. 6
From: Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis
Direct downregulation of CAMP gene promoter activity by DNA methylation. a A schematic illustration of the CAMP gene promoter. The major transcriptional start site is indicated by the arrow at position +1. Upper tick marks indicate individual CpG sites in CAMP gene promoter. The symbols of “#” represent HpaII sites. b Luciferase activities of unmethylated and methylated CAMP gene promoter constructs in HC-OA cells. SAM, S-adenosylmethionine. ***p < 0.001, compared with Control