From: COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy
SARS-CoV-2 susceptibility gene variant or haplotype | Risk estimated [OR] | Frequency [MAF] | References |
---|---|---|---|
TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, IFNAR2 (autosomal-dominant model) | 9 | <0.001 | Zhang et al. [31] |
IRF7, IFNAR1 (autosomal-recessive model) | >50 | <0.001 | Zhang et al. [31] |
rs769208985—missense variant of FURIN | N.A. | <0.001 | Latini et al. [32] |
rs150892504—missense variant of ERAP2 | N.A. | 0.002 | Hu et al. [33] |
rs138763430—missense variant of BRF2 | N.A. | 0.002 | Hu et al. [33] |
rs147149459—missense variant of ALOXE3 | N.A. | 0.002 | Hu et al. [33] |
rs117665206—missense variant of TMEM181 | N.A. | 0.006 | Hu et al. [33] |
rs114363287—missense variant of TMPRSS2 | N.A. | 0.006 | Latini et al. [32] |
HLA DRB*27:07 | N.A. | 0.02 | Novelli et al. [34] |
rs74956615—3′UTR variant of TYK2 | 1.6 | 0.03 | Pairo-Castineira et al. [35] |
rs73064425—intronic variant of LZTFL1 | 2.1 | 0.08 | |
rs11385942—intronic variant of LZTFL1 | 1.8 | 0.07 | Ellinghaus et al [36] |
HLA DQB1*06:02 | N.A. | 0.08 | Novelli et al. [34] |
rs143334143—intronic variant of CCHCR1 | 1.9 | 0.09 | Pairo-Castineira et al. [35] |
HLA DRB1*15:01 | N.A. | 0.10 | Novelli et al. [34] |
rs6598045—5′UTR variant of IFITM3 | N.A. | 0.19 | Kim et al. [37] |
rs429358—missense variant of APOE | 2.3-2.4 | 0.20 | Kuo et al. [38] |
rs9380142—3′UTR variant of HLA-G | 13 | 0.29 | Pairo-Castineira et al. [35] |
rs2109069—intronic variant of DPP9 | 1.4 | 0.33 | Pairo-Castineira et al. [35] |
rs75603675—missense variant of TMPRSS2 | N.A. | 0.36 | Latini et al. [32] |
rs12329760—missense variant of TMPRSS2 | 0.9 | 0.39 | Hou et al. [39] |
rs657152—intronic variant of ABO | 1.3 | 0.41 | Ellinghaus et al. [36] |
rs6020298—intronic variant of TMEM189-UBE2V1 | 1.2 | 0.58 | Wang et al. [40] |
rs10735079—intronic variant of OAS1/3 | 1.3 | 0.64 | Pairo-Castineira et al. [35] |
rs2236757—intronic variant of IFNAR2 | 1.3 | 0.71 | Pairo-Castineira et al. [35] |
rs3131294—intronic variant of NOTCH4 | 1.5 | 0.9 | Pairo-Castineira et al. [35] |
HLA B*46:01 | 2.1 | N.A. | Lin et al. [41] |
HLA-E*0101/0103 | 2.1/2.7 | N.A. | Vietzen et al. [42] |
KLRC2del | 2.6/7.1 | N.A. | Vietzen et al. [42] |
HLA B*54:01 | 5.4 | N.A. | Lin et al. [41] |
c.2129_2132del, p.Gln710Argfs*18—frameshift variant of TLR7 | N.A. | N.A. | van der Made et al. [43] |
c.2383G>T, p.Val795Phe—missense variant of TLR7 | N.A. | N.A. | van der Made et al. [43] |
rs140312271—missense variant of ACE2 | N.A. | N.A. | Novelli et al. [44] |