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Table 2 Genetic risk factors for severe COVID-19

From: COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy

SARS-CoV-2 susceptibility gene variant or haplotype Risk estimated [OR] Frequency [MAF] References
TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, IFNAR2 (autosomal-dominant model) 9 <0.001 Zhang et al. [31]
IRF7, IFNAR1 (autosomal-recessive model) >50 <0.001 Zhang et al. [31]
rs769208985—missense variant of FURIN N.A. <0.001 Latini et al. [32]
rs150892504—missense variant of ERAP2 N.A. 0.002 Hu et al. [33]
rs138763430—missense variant of BRF2 N.A. 0.002 Hu et al. [33]
rs147149459—missense variant of ALOXE3 N.A. 0.002 Hu et al. [33]
rs117665206—missense variant of TMEM181 N.A. 0.006 Hu et al. [33]
rs114363287—missense variant of TMPRSS2 N.A. 0.006 Latini et al. [32]
HLA DRB*27:07 N.A. 0.02 Novelli et al. [34]
rs74956615—3′UTR variant of TYK2 1.6 0.03 Pairo-Castineira et al. [35]
rs73064425—intronic variant of LZTFL1 2.1 0.08 Pairo-Castineira et al. [35], Ellinghaus et al. [36]
rs11385942—intronic variant of LZTFL1 1.8 0.07 Ellinghaus et al [36]
HLA DQB1*06:02 N.A. 0.08 Novelli et al. [34]
rs143334143—intronic variant of CCHCR1 1.9 0.09 Pairo-Castineira et al. [35]
HLA DRB1*15:01 N.A. 0.10 Novelli et al. [34]
rs6598045—5′UTR variant of IFITM3 N.A. 0.19 Kim et al. [37]
rs429358—missense variant of APOE 2.3-2.4 0.20 Kuo et al. [38]
rs9380142—3′UTR variant of HLA-G 13 0.29 Pairo-Castineira et al. [35]
rs2109069—intronic variant of DPP9 1.4 0.33 Pairo-Castineira et al. [35]
rs75603675—missense variant of TMPRSS2 N.A. 0.36 Latini et al. [32]
rs12329760—missense variant of TMPRSS2 0.9 0.39 Hou et al. [39]
rs657152—intronic variant of ABO 1.3 0.41 Ellinghaus et al. [36]
rs6020298—intronic variant of TMEM189-UBE2V1 1.2 0.58 Wang et al. [40]
rs10735079—intronic variant of OAS1/3 1.3 0.64 Pairo-Castineira et al. [35]
rs2236757—intronic variant of IFNAR2 1.3 0.71 Pairo-Castineira et al. [35]
rs3131294—intronic variant of NOTCH4 1.5 0.9 Pairo-Castineira et al. [35]
HLA B*46:01 2.1 N.A. Lin et al. [41]
HLA-E*0101/0103 2.1/2.7 N.A. Vietzen et al. [42]
KLRC2del 2.6/7.1 N.A. Vietzen et al. [42]
HLA B*54:01 5.4 N.A. Lin et al. [41]
c.2129_2132del, p.Gln710Argfs*18—frameshift variant of TLR7 N.A. N.A. van der Made et al. [43]
c.2383G>T, p.Val795Phe—missense variant of TLR7 N.A. N.A. van der Made et al. [43]
rs140312271—missense variant of ACE2 N.A. N.A. Novelli et al. [44]
  1. MAF major allele frequency, N.A. not applicable, OR odds ratio