Skip to main content

Table 2 Genetic risk factors for severe COVID-19

From: COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy

SARS-CoV-2 susceptibility gene variant or haplotype

Risk estimated [OR]

Frequency [MAF]

References

TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, IFNAR2 (autosomal-dominant model)

9

<0.001

Zhang et al. [31]

IRF7, IFNAR1 (autosomal-recessive model)

>50

<0.001

Zhang et al. [31]

rs769208985—missense variant of FURIN

N.A.

<0.001

Latini et al. [32]

rs150892504—missense variant of ERAP2

N.A.

0.002

Hu et al. [33]

rs138763430—missense variant of BRF2

N.A.

0.002

Hu et al. [33]

rs147149459—missense variant of ALOXE3

N.A.

0.002

Hu et al. [33]

rs117665206—missense variant of TMEM181

N.A.

0.006

Hu et al. [33]

rs114363287—missense variant of TMPRSS2

N.A.

0.006

Latini et al. [32]

HLA DRB*27:07

N.A.

0.02

Novelli et al. [34]

rs74956615—3′UTR variant of TYK2

1.6

0.03

Pairo-Castineira et al. [35]

rs73064425—intronic variant of LZTFL1

2.1

0.08

Pairo-Castineira et al. [35], Ellinghaus et al. [36]

rs11385942—intronic variant of LZTFL1

1.8

0.07

Ellinghaus et al [36]

HLA DQB1*06:02

N.A.

0.08

Novelli et al. [34]

rs143334143—intronic variant of CCHCR1

1.9

0.09

Pairo-Castineira et al. [35]

HLA DRB1*15:01

N.A.

0.10

Novelli et al. [34]

rs6598045—5′UTR variant of IFITM3

N.A.

0.19

Kim et al. [37]

rs429358—missense variant of APOE

2.3-2.4

0.20

Kuo et al. [38]

rs9380142—3′UTR variant of HLA-G

13

0.29

Pairo-Castineira et al. [35]

rs2109069—intronic variant of DPP9

1.4

0.33

Pairo-Castineira et al. [35]

rs75603675—missense variant of TMPRSS2

N.A.

0.36

Latini et al. [32]

rs12329760—missense variant of TMPRSS2

0.9

0.39

Hou et al. [39]

rs657152—intronic variant of ABO

1.3

0.41

Ellinghaus et al. [36]

rs6020298—intronic variant of TMEM189-UBE2V1

1.2

0.58

Wang et al. [40]

rs10735079—intronic variant of OAS1/3

1.3

0.64

Pairo-Castineira et al. [35]

rs2236757—intronic variant of IFNAR2

1.3

0.71

Pairo-Castineira et al. [35]

rs3131294—intronic variant of NOTCH4

1.5

0.9

Pairo-Castineira et al. [35]

HLA B*46:01

2.1

N.A.

Lin et al. [41]

HLA-E*0101/0103

2.1/2.7

N.A.

Vietzen et al. [42]

KLRC2del

2.6/7.1

N.A.

Vietzen et al. [42]

HLA B*54:01

5.4

N.A.

Lin et al. [41]

c.2129_2132del, p.Gln710Argfs*18—frameshift variant of TLR7

N.A.

N.A.

van der Made et al. [43]

c.2383G>T, p.Val795Phe—missense variant of TLR7

N.A.

N.A.

van der Made et al. [43]

rs140312271—missense variant of ACE2

N.A.

N.A.

Novelli et al. [44]

  1. MAF major allele frequency, N.A. not applicable, OR odds ratio