Name | Distribution (kb) | Locus | Sugar donor | Isoform | Substrates | Function | References |
---|---|---|---|---|---|---|---|
UGT1 | 200 | 2q37 | UDP-glucuronic acid | UGT1A1, 1A3-1A10 | Endogenous lipophilic compounds: bilirubin, steroid hormones, bile acids, and fatty acids Exogenous lipophilic chemicals: carcinogens, environmental toxicants and pollutants | Detoxify and clear of endogenous and exogenous lipophilic compounds | |
UGT2 | 1500 | 4q13 | UDP-glucuronic acid | UGT2A: UGT2A1-2A3 UGT2B: UGT2B4, 7, 10, 11, 15, 17, 28 | Same as above | Same as above | [3] |
UGT3 | 115 | 5p13.2 | UDP-N-acetylglucosamine, UDP-glucose, UDP-xylose | UGT3A1, UGT3A2 | Ursodeoxycholic acid, 17 alpha-estradiol, 17 beta-estradiol, 4-nitrophenol, 5-1-naphthol | Responsible for the formation of N-acetylglucosaminides of UDCA and other compounds | |
UGT8 | Over>40kb | 4q26 | UDP-galactose | UGT8 | Ceramide, deoxycholic acid, chenodeoxycholic acid, cholic acid, hyodeoxycholic acid, 4 ursodeoxycholic acid | 1. Responsible for the biosynthesis of galactosylceramide and psychosine 2. A modulator of bile acid homeostasis and signaling |