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Table 1 UGT gene information table

From: Epigenetics and microRNAs in UGT1As

Name

Distribution (kb)

Locus

Sugar donor

Isoform

Substrates

Function

References

UGT1

200

2q37

UDP-glucuronic acid

UGT1A1, 1A3-1A10

Endogenous lipophilic compounds: bilirubin, steroid hormones, bile acids, and fatty acids

Exogenous lipophilic chemicals: carcinogens, environmental toxicants and pollutants

Detoxify and clear of endogenous and exogenous lipophilic compounds

[7, 8]

UGT2

1500

4q13

UDP-glucuronic acid

UGT2A: UGT2A1-2A3

UGT2B: UGT2B4, 7, 10, 11, 15, 17, 28

Same as above

Same as above

[3]

UGT3

115

5p13.2

UDP-N-acetylglucosamine, UDP-glucose, UDP-xylose

UGT3A1, UGT3A2

Ursodeoxycholic acid, 17 alpha-estradiol, 17 beta-estradiol, 4-nitrophenol, 5-1-naphthol

Responsible for the formation of N-acetylglucosaminides of UDCA and other compounds

[6, 9]

UGT8

Over>40kb

4q26

UDP-galactose

UGT8

Ceramide, deoxycholic acid, chenodeoxycholic acid, cholic acid, hyodeoxycholic acid, 4 ursodeoxycholic acid

1. Responsible for the biosynthesis of galactosylceramide and psychosine

2. A modulator of bile acid homeostasis and signaling

[10,11,12]