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Table 1 Demographic characteristics of the 50679 pregnancies examined by NIPT

From: Performances of NIPT for copy number variations at different sequencing depths using the semiconductor sequencing platform

Characteristic

NIPT

NIPT-PLUS

p

Total

42969 (100.00%)

7710 (100.00%)

 

Mean age when performed NIPT (SD), years

31.2 ± 12.8

31.0 ± 10.3

0.07

Singleton pregnancy

41594 (96.8%)

7304 (94.73)

1.2E−19

Twin pregnancy

1375 (3.2%)

406 (5.27%)

1.2E−19

Gestational age at NIPT

   

 12~19+6 weeks

23048 (53.64%)

5005 (67.55%)

3.9E−75

 20~23+6 weeks

11370 (26.46%)

1565 (21.12%)

3E−30

 24~29+6 weeks

5036 (11.72%)

824 (11.12%)

0.00903

 30~34+6 weeks

3279 (7.63%)

311 (4.2%)

8.6E−30

 ≥ 35 weeks

236 (0.55%)

5 (0.07%)

1.3E−08

Serological screening for high or intermediate risks

20592 (47.92%)

4251 (55.14%)

1.3E−33

Serological screening for the single marker value abnormality (AFP, β-HCG,uE3)

12357 (28.76%)

872 (11.31%)

2E−226

Ultrasound soft-marker abnormalities

4691 (10.92%)

1539 (19.96%)

7E−110

Isolated advanced maternal age (≥ 35 years, AMA)

5094 (11.86%)

995 (12.91%)

0.01

Othera

235 (0.55%)

53 (0.69%)

0.13

IVF pregnancies

2535 (5.9%)

711 (9.22%)

5.3E−28

Fetal fragment fraction

13.11%

17.37%

 
  1. aPrevious adverse outcome of pregnancy; previous pregnancy history of chromosomal abnormalities fetus