Characteristic | NIPT | NIPT-PLUS | p |
---|---|---|---|
Total | 42969 (100.00%) | 7710 (100.00%) | Â |
Mean age when performed NIPT (SD), years | 31.2 ± 12.8 | 31.0 ± 10.3 | 0.07 |
Singleton pregnancy | 41594 (96.8%) | 7304 (94.73) | 1.2E−19 |
Twin pregnancy | 1375 (3.2%) | 406 (5.27%) | 1.2E−19 |
Gestational age at NIPT | Â | Â | Â |
 12~19+6 weeks | 23048 (53.64%) | 5005 (67.55%) | 3.9E−75 |
 20~23+6 weeks | 11370 (26.46%) | 1565 (21.12%) | 3E−30 |
 24~29+6 weeks | 5036 (11.72%) | 824 (11.12%) | 0.00903 |
 30~34+6 weeks | 3279 (7.63%) | 311 (4.2%) | 8.6E−30 |
 ≥ 35 weeks | 236 (0.55%) | 5 (0.07%) | 1.3E−08 |
Serological screening for high or intermediate risks | 20592 (47.92%) | 4251 (55.14%) | 1.3E−33 |
Serological screening for the single marker value abnormality (AFP, β-HCG,uE3) | 12357 (28.76%) | 872 (11.31%) | 2E−226 |
Ultrasound soft-marker abnormalities | 4691 (10.92%) | 1539 (19.96%) | 7E−110 |
Isolated advanced maternal age (≥ 35 years, AMA) | 5094 (11.86%) | 995 (12.91%) | 0.01 |
Othera | 235 (0.55%) | 53 (0.69%) | 0.13 |
IVF pregnancies | 2535 (5.9%) | 711 (9.22%) | 5.3E−28 |
Fetal fragment fraction | 13.11% | 17.37% | Â |