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Table 6 Association results between blood cell count traits and MT-CN polygenic risk score in 357656 UK Biobank samples. β refers to the regression coefficient of MT-CN in a linear regression of cell type onto MT-CN PRS and other covariates (see Methods). Bolded results are significant below a nominal α = 0.05.

From: Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Cell type All samples No post hoc high-leverage outliers
β SE P β SE P
Leukocyte − 0.00856 0.00170 4.42 × 10-7 - - -
Monocyte − 0.00119 0.00170 0.482 - - -
Lymphocyte − 0.00250 0.00170 0.142 - - -
Neutrophil − 0.00954 0.00169 1.80 × 10-8 − 0.00948 0.00169 2.17 × 10-8
Platelet 0.00548 0.00170 1.24 × 10-3 0.00548 0.00170 1.25 × 10-3