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Table 7 Association results between metabolic syndrome traits and MT-CN polygenic risk score in 357656 UK Biobank samples. β refers to the regression coefficient of MT-CN in a linear regression of cell type onto MT-CN PRS and other covariates (see Methods). Bolded results are significant below a nominal α = 0.05. The weight phenotype tested was that which was measured at the time of impedance measurement.

From: Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Trait

Without platelet and neutrophil adjustment

With platelet and neutrophil adjustment

β

SE

P

β

SE

P

Type 2 diabetes

− 0.1681

0.0826

0.0419

− 0.1467

0.0844

0.0823

BMI

− 0.0372

0.0175

0.0331

− 0.0233

0.0175

0.1836

Fat mass

− 0.0452

0.0176

0.0100

− 0.0318

0.0177

0.0716

C-reactive protein

− 0.0015

0.0178

0.9305

0.0206

0.0171

0.2291

HDL

0.0573

0.0187

0.0021

0.0416

0.0187

0.0262

Total triglycerides

− 0.0500

0.0176

0.0046

− 0.0330

0.0175

0.0603

Weight

− 0.0359

0.0176

0.0414

− 0.0218

0.0178

0.2189