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Table 7 Association results between metabolic syndrome traits and MT-CN polygenic risk score in 357656 UK Biobank samples. β refers to the regression coefficient of MT-CN in a linear regression of cell type onto MT-CN PRS and other covariates (see Methods). Bolded results are significant below a nominal α = 0.05. The weight phenotype tested was that which was measured at the time of impedance measurement.

From: Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Trait Without platelet and neutrophil adjustment With platelet and neutrophil adjustment
β SE P β SE P
Type 2 diabetes − 0.1681 0.0826 0.0419 − 0.1467 0.0844 0.0823
BMI − 0.0372 0.0175 0.0331 − 0.0233 0.0175 0.1836
Fat mass − 0.0452 0.0176 0.0100 − 0.0318 0.0177 0.0716
C-reactive protein − 0.0015 0.0178 0.9305 0.0206 0.0171 0.2291
HDL 0.0573 0.0187 0.0021 0.0416 0.0187 0.0262
Total triglycerides − 0.0500 0.0176 0.0046 − 0.0330 0.0175 0.0603
Weight − 0.0359 0.0176 0.0414 − 0.0218 0.0178 0.2189