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Table 4 Genotype/minor-allele frequency distributions of the ACAN, BGN, DCN and VCAN polymorphisms for shoulder pain categories

From: Regulatory VCAN polymorphism is associated with shoulder pain and disability in breast cancer survivors

Gene

SNP

Genotype or allele

No–low

(n = 170)

Moderate–high

(n = 61)

p value

ACAN

rs1126823 A>G

G/G

29 (50)

33 (20)

0.609 (0.459)

A/G

45 (76)

47 (29)

A/A

26 (44)

20 (12)

A

48 (164)

43 (53)

0.398

rs1516797 T>G

G/G

28 (47)

29 (18)

0.856 (0.959)

G/T

44 (75)

46 (28)

T/T

28 (48)

25 (15)

T

50 (171)

48 (58)

0.673

rs2882676 A>C

A/A

32 (54)

27 (16)

0.724 (0.591)

A/C

46 (78)

48 (29)

C/C

22 (37)

25 (15)

C

45 (152)

49 (59)

0.456

BGN

rs1042103 G>A

G/G

74 (125)

70 (43)

0.350 (0.766)

A/G

24 (41)

23 (14)

A/A

2 (4)

7 (4)

A

14 (49)

18 (22)

0.380

rs743641 A>T

A/A

48 (82)

46 (28)

0.801 (0.763)

A/T

42 (71)

41 (25)

T/T

10 (17)

13 (8)

T

31 (105)

34 (41)

0.573

rs743642 G>T

G/G

54 (92)

52 (32)

0.476 (0.451)

G/T

39 (67)

36 (22)

T/T

7 (11)

12 (7)

T

26 (89)

30 (36)

0.478

DCN

rs516115 C>T

T/T

29 (49)

30 (18)

0.684 (0.572)

C/T

53 (90)

48 (29)

C/C

18 (31)

23 (14)

C

45 (152)

47 (57)

0.751

VCAN

rs11726 A>G

G/G

29 (49)

48 (29)

0.004 (0.005)

A/G

55 (94)

31 (19)

A/A

16 (27)

21 (13)

A

44 (148)

37 (45)

0.239

rs2287926 G>A

G/G

66 (112)

59 (36)

0.398 (0.374)

A/G

29 (49)

38 (23)

A/A

5 (9)

3 (2)

A

20 (67)

22 (27)

0.601

rs309559 A>G

G/G

26 (44)

29 (18)

0.863 (0.877)

A/G

49 (83)

46 (28)

A/A

25 (42)

25 (15)

A

49 (167)

48 (58)

0.752

  1. Notes: Genotype and allele frequencies are expressed as a percentage with the number of participants (n) in parentheses. p values in bold typeset indicate significance (p < 0.05), whereas p values in parentheses are adjusted for participants’ age at consent.
  2. Abbreviations: ACAN, Aggrecan; BGN, Biglycan; DCN, Decorin; VCAN, Versican.