Fig. 3
From: Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome
ME cell population clustering analysis with differentially accessible peak analysis. A UMAP plot of megakaryocyte erythroid cells. Cluster 0 is marked 0, and cluster 1 is marked 1. B Proportions of cells in the ES and NC groups: megakaryocyte erythroid cells, cluster 0 labelled ME-0, cluster 1 labelled ME-1. C Genes co-regulated by ME-0 and ME-1 had significantly differential peaks (p < 0.05, log2FC > 1). D Number of motifs significantly upregulated by ME-0 and ME-1 (p < 0.05, log2FC > 0.58). E ME-0 differentially expressed genes (p < 0.05, |log2FC| > 1). Blue dots indicate downregulated genes, red dots indicate upregulated genes, and grey dots indicate genes that are satisfactorily significantly different and label the five genes with the largest multiplicity of differences. F ME-1 differentially expressed genes (p < 0.05, |log2FC| < 1). G Results of GO enrichment analysis of ME-0 and ME-1. F Results of KEGG enrichment analysis of ME-0 and ME-1