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Fig. 4 | Human Genomics

Fig. 4

From: Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome

Fig. 4

Molecular characterization of progenitor cells. A Top 10 network progenitor cells ranked by the degree method. The network diagram shows how the hub gene interacts with other genes. The redder the box, the higher the score, indicating a more critical gene. B UMAP plot of progenitor cells. Cluster 0 is marked 0, and cluster 1 is marked 1. C Proportion of cells in the ES and NC groups in progenitor cells, cluster 0 labelled P-0, cluster 1 labelled P-1. D P-0 differentially expressed genes (p < 0.05, |log2FC| > 1). Blue dots indicate downregulated genes, red dots indicate upregulated genes, and grey dots indicate genes that are satisfactorily significantly different and label the five genes with the largest multiplicity of differences. E P-1 differentially expressed genes (p < 0.05, |log2FC| < 1). F Genes co-regulated by P-0 and P-1 had significantly different peaks (p < 0.05, log2FC > 1). G Results of GO enrichment analysis of P-0 and P-1

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