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Fig. 1 | Human Genomics

Fig. 1

From: HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression

Fig. 1

HCP5 and PIK3R5 expression were all increased in AML tissues, which correlated with unfavorable survival-term. (A-B) Gene set enrichment analysis (GSEA) was conducted with TCGA and GTEx database, and the plots revealed that a series of gene sets including acute myeloid leukemia pathway and apoptosis pathway. (C) Venn diagram of additive genes covered by both acute myeloid leukemia pathway and apoptosis pathway. (D) The expression of PIK3R5 was determined in AML tissues (n = 151) and normal controls (n = 70) on the basis of TCGA and GTEx databases. P < 0.0001. (E) Kaplan-Meier analysis exhibited that high PIK3R5 expression was associated with adverse overall survival. P = 0.018. (F) Pearson correlation analysis showed that HCP5 was positively related with PIK3R5. P < 0.0001, r = 0.7677. (G) HCP5 expression in AML tissue specimens (n = 151) and normal cases (n = 70). P < 0.0001. (H) Overall survival rates of AML patients with different HCP5 expression were detected by Kaplan-Meier method. P = 0.00094

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