Description | Gene marker | CDK1 | HMMR | PTTG1 | TTK | ||||
---|---|---|---|---|---|---|---|---|---|
Cor | P | Cor | P | Cor | P | Cor | P | ||
CD8+ T cell | CD8A | 0.198 | *** | 0.139 | ** | 0.164 | ** | 0.188 | *** |
CD8B | 0.184 | *** | 0.096 | 0.064 | 0.226 | *** | 0.165 | ** | |
T cell (general) | CD3D | 0.274 | *** | 0.154 | ** | 0.333 | *** | 0.266 | *** |
CD3E | 0.202 | *** | 0.120 | * | 0.175 | *** | 0.195 | *** | |
CD2 | 0.216 | *** | 0.121 | * | 0.204 | *** | 0.204 | *** | |
B cell | CD19 | 0.273 | *** | 0.204 | *** | 0.247 | *** | 0.273 | *** |
CD79A | 0.158 | ** | 0.065 | 0.212 | 0.116 | * | 0.177 | *** | |
Monocyte | CD86 | 0.284 | *** | 0.266 | *** | 0.250 | *** | 0.283 | *** |
CD115 | 0.131 | * | 0.138 | ** | 0.102 | * | 0.119 | * | |
TAM | CCL2 | 0.039 | 0.459 | 0.023 | 0.656 | − 0.023 | 0.665 | 0.021 | 0.682 |
CD68 | 0.230 | *** | 0.186 | *** | 0.149 | * | 0.204 | *** | |
IL10 | 0.219 | *** | 0.223 | *** | 0.156 | * | 0.235 | *** | |
M1 macrophage | NOS2 | − 0.020 | 0.695 | 0.080 | 0.123 | − 0.140 | ** | − 0.005 | 0.926 |
IRF5 | 0.394 | *** | 0.407 | *** | 0.291 | *** | 0.373 | *** | |
COX2 | 0.101 | 0.053 | 0.071 | 0.171 | − 0.025 | 0.637 | 0.094 | 0.070 | |
M2 Macrophage | CD163 | 0.067 | 0.197 | 0.153 | ** | − 0.022 | 0.676 | 0.073 | 0.160 |
VSIG4 | 0.080 | 0.123 | 0.138 | ** | 0.024 | 0.647 | 0.059 | 0.255 | |
MS4A4A | 0.089 | 0.086 | 0.142 | ** | 0.027 | 0.601 | 0.079 | 0.128 | |
Neutrophils | CD66b | 0.123 | * | 0.096 | 0.066 | 0.094 | 0.071 | 0.107 | * |
CD11b | 0.257 | *** | 0.333 | *** | 0.237 | *** | 0.280 | *** | |
CCR7 | 0.089 | 0.086 | 0.045 | 0.385 | − 0.030 | 0.569 | 0.070 | 0.181 | |
Natural killer cell | KIR3DL1 | 0.010 | 0.843 | 0.068 | 0.189 | − 0.053 | 0.308 | 0.009 | 0.869 |
KIR2DL1 | − 0.035 | 0.500 | − 0.023 | 0.656 | − 0.068 | 0.190 | − 0.044 | 0.393 | |
KIR2DS4 | 0.075 | 0.148 | 0.076 | 0.142 | 0.029 | 0.581 | 0.044 | 0.400 | |
Dendritic cell | CD11C | 0.331 | *** | 0.310 | *** | 0.246 | *** | 0.326 | *** |
CD1C | 0.121 | * | 0.066 | 0.204 | 0.041 | 0.434 | 0.104 | * | |
NRP1 | 0.231 | *** | 0.195 | *** | 0.005 | 0.916 | 0.180 | *** | |
PDL1 | CD274 | 0.209 | *** | 0.334 | *** | 0.062 | 0.230 | 0.062 | 0.230 |
Th l | STAT4 | 0.262 | *** | 0.179 | *** | 0.215 | *** | 0.246 | *** |
STAT1 | 0.372 | *** | 0.372 | *** | 0.248 | *** | 0.398 | *** | |
TBX21 | 0.081 | 0.119 | 0.050 | 0.341 | 0.018 | 0.736 | 0.084 | 0.107 | |
CD4 | 0.222 | *** | 0.232 | *** | 0.123 | * | 0.228 | *** | |
IFNG | 0.266 | *** | 0.219 | *** | 0.285 | *** | 0.275 | *** | |
Th 2 | GATA3 | 0.203 | *** | 0.135 | ** | 0.133 | * | 0.185 | *** |
STAT6 | 0.114 | * | 0.192 | *** | − 0.108 | * | 0.115 | * | |
CXCR4 | 0.315 | *** | 0.224 | *** | 0.204 | *** | 0.292 | *** | |
CCR4 | 0.206 | *** | 0.220 | *** | − 0.023 | 0.663 | 0.213 | *** | |
Treg | FOXP3 | 0.163 | ** | 0.271 | *** | 0.023 | 0.655 | 0.205 | *** |
CCR8 | 0.392 | *** | 0.418 | *** | 0.209 | *** | 0.403 | *** | |
STAT5B | 0.247 | *** | 0.355 | *** | − 0.022 | 0.676 | 0.278 | *** | |
TGFB1 | 0.278 | *** | 0.174 | *** | 0.207 | *** | 0.253 | *** | |
T cell exhaustion | PD-1 | 0.330 | *** | 0.196 | *** | 0.333 | *** | 0.308 | *** |
CTLA4 | 0.357 | *** | 0.244 | *** | 0.384 | *** | 0.348 | *** | |
LAG3 | 0.294 | *** | 0.205 | *** | 0.348 | *** | 0.318 | *** | |
TIM-3 | 0.296 | *** | 0.281 | *** | 0.272 | *** | 0.289 | *** | |
GZMB | 0.092 | 0.078 | 0.048 | 0.355 | 0.123 | * | 0.065 | 0.212 |