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Fig. 2 | Human Genomics

Fig. 2

From: High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma

Fig. 2

Differentially expressed mRNA profile identified by sequencing. A Clustering dendrogram of the mRNA data. B The volcano plot showing change of all DEGs between TSC-RAML and normal kidney tissue. Each pink dot stands for one DEG. The x-axis indicates the log2-transformed fold change, and the y-axis refers to the -log10-transformed false discovery rate (FDR). C Cluster heatmap showing the expression of all DEGs.D Venn diagram showing the overlap of DEGs between the current study and our previous microarray mRNA chip study. Six genes were found to be overlap DEGs between the two studies, including MALT1, UBFD1, AMACR (up-regulated DEGs), KCNK3, ABAT, and STUM (down-regulated DEGs). E GSVA analysis of the mTOR pathway. The TSC-RAML group have higher mTOR GSVA scores than the control group (P = 0.0026, E)

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Human Genomics

ISSN: 1479-7364