Fig. 1

Pedigree trees for the seven families studied. Squares represent males, circles represent females, and diamonds represent any sex, with numbers representing more than one individual. Diagonal lines indicate that the individual is deceased. Double horizontal bars represent consanguineous marriages and a dotted line suggests consanguinity without support from the full pedigree tree. Black fill indicates affected status, white indicates unaffected and gray indicates risk. Family members genotyped in this study are marked with an asterisk (*). Arrows indicate probands