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Fig. 1 | Human Genomics

Fig. 1

From: Identification of subgroups along the glycolysis-cholesterol synthesis axis and the development of an associated prognostic risk model

Fig. 1

Stratification of SKCM tumors based on expression of glycolysis and cholesterogenic genes. A The CDF curve under different values of k. The value of k represents the number of clusters during the consensus cluster. When the optimal k value is reached, the area under the CDF curve will not significantly increase with the increase of k value. B Heatmap depicting consensus clustering solution (k=6) for glycolysis and cholesterogenic genes in SCKM samples (n=469). C Scatter plot showing median expression levels of co-expressed glycolytic (x-axis) and cholesterogenic (y-axis) genes in each SKCM sample. Metabolic subgroups were assigned on the basis of the relative expression levels of glycolytic and cholesterogenic genes. D Heatmap depicting expression levels of co-expressed glycolytic and cholesterogenic genes across each subgroup. E PCA showed that patients in the different subtgroups were significantly different from each other. F Kaplan-Meier survival curves for patients in the different subgroups. Log-rank test P values are shown. The clinical outcome endpoint is OS. G Kaplan-Meier survival curves for patients in the different subgroups. Log-rank test P value is shown. The clinical outcome endpoint is PFI. SKCM, skin cutaneous melanoma; CDF, cumulative distribution function; PCA, principal components analysis; OS, overall survival; PFI, progression-free interval. And P < 0.05 is defined as statistically significant

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Human Genomics

ISSN: 1479-7364