Fig. 1

Computational structural analysis of novel variants. Mapping of the mutations onto the TTR tetramer. A The TTR tetramer (each chain is color-coded) bound to RBP (gray) and thyroxin (thy, red). The mutated residues are shown as sphere models, corresponding to the frames with the zoomed-in regions. For clarity, not all residues are labeled. Note that the RBP binding environment of the same residue is different in different TRR chains. B–D The local environment of each mutated residue. The side chains of the variants are shown in green. C The red spheres illustrate the steric clashes resulting from the mutation