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Table 4 Putative target genes of the differentially expressed miRNAs in plasma-derived exosomes in four patients with TRD compared to four healthy control subjects

From: Abnormal expression profile of plasma-derived exosomal microRNAs in patients with treatment-resistant depression

Genes NO. of miRNAs targeted miRNA expression Reference(s) Function(s)
ADRA1B 1 (has-miR-1292-3p) Down [33] GABA, serotonin
ADRB1 1 (has-miR-1292-3p) Down [34] Synapsin
CACNA1C 1 (has-miR-1292-3p) Down [35] Synapsin Dopamine Glutamate Adrenergic
CREB1 1 (has-miR-1292-3p) Down [36] Synapsin Dopamine NMDA Glutamate serotonin
FGFR1 1 (has-miR-1292-3p) Down [37] Dopamine
GNAS 1 (has-miR-1292-3p) Down [38] Synapsin Glutamate serotonin
GRIK5 1 (has-miR-1292-3p) Down [33] Synapsin Dopamine NMDA Glutamate GABA
HTR1A 1 (has-miR-1292-3p) Down [39] Synapsin Glutamate
NOS1 1 (has-miR-1292-3p) Down [40] Serotonin Dopamine NMDA Glutamate GABA Adrenergic
OPRM1 1 (has-miR-1292-3p) Down [41] Synapsin Dopamine Glutamate GABA Adrenergic
P2RX7 1 (has-miR-1292-3p) Down [42] Glutamate GABA
PDE10A 1 (has-miR-1292-3p) Down [43] Synapsin
NUFIP2 1 (has-miR-335-5p) Up [44] MDD
TCF4 1 (has-miR-335-5p) Up [44] MDD