Table 1 Genetic risk factors for severe COVID-19

TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, IFNAR2 (autosomal-dominant model)

9

 < 0.001

Zhang et al. [20]

IRF7, IFNAR1 (autosomal-recessive model)

 > 50

 < 0.001

Zhang et al. [20]

rs769208985—missense variant of FURIN

N.A

 < 0.001

Latini et al. [71]

rs150892504—missense variant of ERAP2

N.A

0.002

Hu et al. [60]

rs138763430—missense variant of BRF2

N.A

0.002

Hu et al. [60]

rs147149459—missense variant of ALOXE3

N.A

0.002

Hu et al. [60]

rs117665206—missense variant of TMEM181

N.A

0.006

Hu et al. [60]

rs114363287—missense variant of TMPRSS2

N.A

0.006

Latini et al. [71]

rs61756766—missense variant of TNFRSF13C

12.3

0.008

Russo et al. [61]

rs7626962—missense variant of SCN5A

8.7

0.008

SeyedAlinaghi et al. [62]

rs1805128—missense variant of KCNE1

9.0

0.009

SeyedAlinaghi et al. [62]

HLA-DRB*27:07

N.A

0.02

Novelli et al. [51]

rs72711165—intronic variant of TMEM65

1.2

0.02

COVID-19 H.G.I. [66]

rs115492982—intronic variant of MRPS21

2.5

0.02

Dite et al. [63]

rs74956615—3'UTR variant of TYK2

1.6

0.03

Pairo-Castineira et al. [11]

rs2034831—intronic variant of ITGA4

1.2

0.05

Dite et al. [63]

rs76374459—intronic variant of LZTFL1

1.2

0.05

Dite et al. [63]

rs35652899—intronic variant of LZTFL1

1.2

0.05

Dite et al. [63]

rs10490770—intronic variant of LZTFL1

2.0

0.06

COVID-19 H.G.I. [66]

rs333—CCR5-Δ32

0.7

0.07

Cuesta-Llavona et al. [76]

rs73064425—intronic variant of LZTFL1

2.1

0.08

Pairo-Castineira et al. [11], Ellinghaus et al. [23]

rs11385942—intronic variant of LZTFL1

1.8

0.07

Ellinghaus et al. [23]

rs1886814—intronic variant of FOXP4

1.3

0.07

COVID-19 H.G.I. [66]

rs76488148—intronic variant of GYG1

1.3

0.07

Dite et al. [63]

rs2271616—5'UTR variant of SLC6A20

1.1

0.08

COVID-19 H.G.I. [66]

HLA-DQB1*06:02

N.A

0.08

Novelli et al. [51]

rs143334143—intronic variant of CCHCR1

1.9

0.09

Pairo-Castineira et al. [11]

HLA-DRB1*15:01

N.A

0.10

Novelli et al. [51]

rs12252:G allele of IFITM3

2.2

0.13

Alghamdi et al. [52]

rs4801778—intronic variant of PLEKHA4

1.0

0.16

COVID-19 H.G.I. [66]

rs6598045—5'UTR variant of IFITM3

N.A

0.19

Kim et al. [53]

rs429358—missense variant of APOE

2.3–2.4

0.20

Kuo et al. [65]

rs12610495—intronic variant of DPP9

N.A

0.25

Moon et al. [41]

rs12329760—intronic variant of TMPRSS2/MX1

0.9

0.25

Andolfo et al. [72]

rs2298661—missense variant of TMPRSS2/MX1

0.9

0.25

Andolfo et al. [72]

rs3787946—intronic variant of TMPRSS2/MX1

0.9

0.28

Andolfo et al. [72]

rs9983330—intronic variant of TMPRSS2/MX1

0.9

0.28

Andolfo et al. [72]

rs9380142—3'UTR variant of HLA-G

13

0.29

Pairo-Castineira et al. [11]

rs2109069—intronic variant of DPP9

1.4

0.33

Pairo-Castineira et al. [11], COVID-19 H.G.I. [66]

rs9985159—intronic variant of TMPRSS2/MX1

0.9

0.33

Andolfo et al. [72]

Rs75603675—missense variant of TMPRSS2

N.A

0.36

Latini et al. [71]

rs1405655—intronic variant of NR1H2

1.1

0.37

COVID-19 H.G.I. [66]

rs12329760—missense variant of TMPRSS2

0.9

0.39

Hou et al. [73]

rs657152—intronic variant of ABO

1.3

0.41

Ellinghaus et al. [23]

rs677800—intronic variant of ABO

N.A

0.55

Moon et al. [41]

rs6020298—intronic variant of TMEM189-UBE2V1

1.2

0.58

Wang et al. [74]

rs10735079—intronic variant of OAS1/3

1.3

0.64

Pairo-Castineira et al. [11]

rs8065800—intronic variant of MAPT

1.7

0.65

COVID-19 H.G.I. [66]

rs10774671—intronic, splicing variant of OAS1

1.1

0.67

COVID-19 H.G.I. [66]

rs13050728—intronic variant of IFNAR2

0.9

0.69

COVID-19 H.G.I. [66]

rs2236757—intronic variant of IFNAR2

1.3

0.71

Pairo-Castineira et al. [11]

rs3131294—intronic variant of NOTCH4

1.5

0.90

Pairo-Castineira et al. [11]

HLA-A*11

N.A

N.A

Fricke-Galindo et al. [54]

HLA-A*11:01:01:01

2.3

N.A

Khor et al. [56]

HLA-A*25:01

N.A

N.A

Fricke-Galindo et al. [54]

HLA-B*46:01

2.1

N.A

Lin et al. [53], Fricke-Galindo et al. [54]

HLA-B*51:01

N.A

N.A

Fricke-Galindo et al. [54]

HLA B*54:01

5.4

N.A

Lin et al. [55]

HLA-C*01

N.A

N.A

Fricke-Galindo et al. [54]

HLA-C*01:02

N.A

N.A

Fricke-Galindo et al. [54]

HLA-C*05

N.A

N.A

Fricke-Galindo et al. [54]

HLA-C*12:02:02:01-HLA*52:01:02:02

2.3

N.A

Khor et al. [56]

HLA-C*14:02

N.A

N.A

Fricke-Galindo et al. [54]

HLA-C*17

N.A

N.A

Bonaccorsi et al. [57]

HLA-DQB1*04

N.A

N.A

Fricke-Galindo et al. [54]

HLA-DQB1*08

N.A

N.A

Fricke-Galindo et al. [54]

HLA-E*0101/0103

2.1–2.7

N.A

Vietzen et al. [58]

KLRC2^del

2.6–7.1

N.A

Vietzen et al. [58]

ACE1 I/D genotype

2.5

N.A

Verma et al. [69]

C9orf72 with HREs > 10 units

2.4

N.A

Zanella et al. [64]

c.2129_2132del, p.Gln710Argfs*18—frameshift variant of TLR7

N.A

N.A

van der Made et al. [42]

c.2383G > T, p.Val795Phe—missense variant of TLR7

N.A

N.A

van der Made et al. [42]

c.644A > G, p.Asn215Ser—missense variant of TLR7

N.A

N.A

Solanich et al. [43]

c.2797 T > C, p.Trp933Arg—missense variant of TLR7

N.A

N.A

Solanich et al. [43]

c.901 T > C, p.Ser301Pro—missense variant of TLR7

N.A

N.A

Fallerini et al. [44]

c.3094G > A, p.Ala1032Thr— missense variant of TLR7

N.A

N.A

Fallerini et al. [44]

c.2759G > A, p.Arg920Lys—missense variant of TLR7

N.A

N.A

Fallerini et al. [44]

c.863C > T, p.Ala288Val—missense variant of TLR7

N.A

N.A

Fallerini et al. [44]

c.1342C > T, p.Ala448Val—missense variant of TLR7

N.A

N.A

Fallerini et al. [44]

c.655G > A, p.Val219Ile—missense variant of TLR7

N.A

N.A

Fallerini et al. [44]

rs140312271—missense variant of ACE2

N.A

N.A

Novelli et al. [75]