Fig. 4

a p.Pro481Ala showing gain of polar contact with p479, b p.Ile355Val, c p.Gln119Pro showing loss of contacts with A115 and A116, d p.Thr76Lys showing loss of some polar contacts with D79, e p.Arg454Cys; a rotamer of this variant clashes with surrounding residues (red spheres), f p.Met159Ile, g p.Ala44Gly, H) p.Phe88Leu, i p.Tyr70Cys showing loss of contact with Q111, j p.Glu156Lys, where the native residue is substituted for the larger residue lysine, k p.Ala149Thr showing gain of polar contacts with V150, l p.Arg74Pro, where the native residue is substituted for the smaller residue, proline, m p.Arg330His, n p.Glu317Lys, o p.Asp282His showing gain of polar contacts with Q449 and R454, loss of contacts with R285; a rotamer of this variant also clashes with surrounding residues, p p.His451Tyr showing gain of polar contacts with Q449 and Q209, Q) Ala335Thr showing minor clash points with surrounding residues (green sphere), and r Pro353Ser showing gain of polar contacts with Gly351