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Fig. 2 | Human Genomics

Fig. 2

From: Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci

Fig. 2

Association between haplotypes combinations (diplotypes) based on the protection conferring CFHR3/1 deletion and CFH I62V and the risk variant CFH Y402H. The common neutral diplotype Neutral/Neutral, which describes the absence of genetic risk or protection, was used as the reference diplotype to describe the full spectrum of AMD susceptibility at the CFH-CFHR5 locus. *Bonferroni correction for multiple testing of 10 diplotypes = 0.005 (0.05/10)

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Human Genomics

ISSN: 1479-7364