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Table 4 Haplotypes based on the protection-conferring CFHR3/1 deletion, CFH I62V and the risk variant CFH Y402H

From: Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci

  1. The common neutral haplotype H3, which describes the absence of genetic risk or protection for developing disease, was used as the reference haplotype to describe the full spectrum of AMD susceptibility at the CFH-CFHR5 locus
  2. *Based on the \({\mathrm{\rm X}}^{2}\)-square test with one degree of freedom
  3. **Bonferroni correction for multiple testing of 4 haplotypes = 0.0125 (0.05/4)
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Human Genomics

ISSN: 1479-7364