Fig. 2

Schematic structure of BRCA1 and BRAC2 proteins showing the identified variants. A Schematic structure of BRCA1. RING domain, Nuclear Localization Signals (NLS), Transactivation domain and BRCT domain are indicated. B Schematic structure of BRCA2. Transactivation domain, BCR repeats, Helical domain and NLS are indicated. Red square = likely pathogenic/pathogenic variants;, orange rhombus = variants of uncertain significance; purple dot = novel variants