Skip to main content

Table 2 Sequence alignment of the BRCA1 and BRCA2 proteins for the two missense VUS identified

From: Breast cancer in West Africa: molecular analysis of BRCA genes in early-onset breast cancer patients in Burkina Faso

SPECIES MATCH GENE AA ALIGNMENT
BRCA1 c.5348T>C (p.Met1783Thr)
Human    1783 T N M P T D Q L E W M V Q L C G A S V V K E L
mutated Not conserved   1783 T N M P T D Q L E W T V Q L C G A S V V K E  
P. troglodytes All identical ENSPTRG00000009236 1783 T N M P T D Q L E W M V Q L C G A S V V K E  
M. mulatta All identical ENSMMUG00000001329 1783 T N M P T D Q L E W M V Q L C G A S V V K E  
F. catus No homologue                          
M. musculus All identical ENSMUSG00000017146 1726 T N M P K D E L E R M L Q L C G A S V V K E  
G. gallus All conserved ENSGALG00000002781 1674 T D M T T G H L E W I V E L C G A S V V K Q  
T. rubripes All identical ENSTRUG00000009091 1207 T D M T T A E M E L M V E L C G A T V V K D  
D. rerio no homologue                          
D. melanogaster no homologue                          
C. elegans No homologue                          
X. tropicalis All identical ENSXETG00000024564 1524 T D M T L D D L E W M V S E C G S T V V R D  
BRCA2 c.7504C>T (p.Arg2502Cys)
Human    2502 D M R I K K K Q R Q R V F P Q P G S L Y L A  
mutated Not conserved   2502 D M R I K K K Q R Q C V F P Q P G S L Y L A  
P. troglodytes All identical ENSPTRG00000005766 2502 D M R I K K K Q R Q R V F P Q P G S L Y L A  
M. mulatta no homologue                          
F. catus No homologue                          
M. musculus Not conserved ENSMUSG00000041147 2423 D M R I K N K E R R H L R L Q P G S L Y L T  
G. gallus Not conserved ENSGALG00000017073 2457 E M R I K K K Y R Q N I S P          
T. rubripes No homologue                          
D. rerio not conserved ENSDARG00000079015 2046 D M R L R K K K R Q T I R P V P G S L Y L A  
D. melanogaster No homologue                          
C. elegans No homologue                          
X. tropicalis All conserved ENSXETG00000017011 2293 E M R I R K K L R Q K I K P H P G S L Y R L