Fig. 2
Preferential location in TAD borders of the SNPs associated to a disease. A Normalized histogram of enrichment p-values (corrected for multiple testing and plotted as [− log10 p] on the horizontal axis) for cancers (yellow bars) and non-cancer diseases (blue bars, overlap in gray), considering the contribution of all SNPs to a potential TAD-border enrichment. The results have been aggregated over datasets for different cell types from [30] at 10 kb-resolution and all considered values of the window parameter k of TopDom algorithm. The two histograms have been normalized separately. The dashed red line indicates the significance threshold at p* = 0.05. B Same as (A) considering only intergenic daSNPs in the hypergeometric enrichment test. C Difference between the cancer histogram, in orange, and the histogram for non-cancer diseases in (A), showing that relatively more cancers display a preferential location of their associated SNPs in TAD borders. D Same as (C) for the histograms in (B), showing that the relative dominance of cancers, among diseases displaying TAD-border enrichment, is enhanced when considering only intergenic daSNPs