A glycolysis-related two-gene risk model that can effectively predict the prognosis of patients with rectal cancer

Table 2 Glycolysis-related GSEA analysis on mRNA expression among COAD and READ patients

The molecular signatures database (MSigDB)	Gene set size	Enrichment score (ES)		Normalized enrichment score (NES)		Nominal p value		FDR q value		FWER p value
The molecular signatures database (MSigDB)		COAD READ		COAD READ		COAD READ		COAD READ		COAD READ
GO_FRUCTOSE_1_6_BISPHOSPHATE_METABOLIC_PROCESS	10	0.56	0.732	1.22	1.507	0.239	0.036	0.239	0.036	0.128	0.023
GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY	6	− 0.47	− 0.352	− 1.11	− 0.771	0.319	0.804	0.319	0.804	0.126	0.268
GO_LACTATE_TRANSPORT	7	− 0.45	− 0.338	− 1.08	− 0.763	0.336	0.811	0.336	0.811	0.142	0.246
REACTOME_GLYCOLYSIS	71	0.67	0.593	1.98	1.568	0.002	0.033	0.002	0.033	0.001	0.019
REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	12	− 0.60	− 0.537	− 1.53	− 1.388	0.051	0.070	0.051	0.070	0.023	0.026
HALLMARK_GLYCOLYSIS	199	0.52	0.436	1.73	1.355	0.004	0.068	0.004	0.068	0.002	0.048
MODULE_306	26	− 0.38	− 0.319	− 0.82	0.714	0.640	0.784	0.640	0.784	0.338	0.338
KEGG_GLYCOLYSIS_GLUCONEOGENESIS	62	− 0.39	− 0.285	− 1.19	− 0.904	0.264	0.636	0.264	0.636	0.128	0.226
KEGG_CITRATE_CYCLE_TCA_CYCLE	31	− 0.64	− 0.542	− 1.46	− 1.282	0.121	0.203	0.121	0.203	0.059	0.092
BIOCARTA_FEEDER_PATHWAY	9	− 0.71	− 0.491	− 1.52	− 1.175	0.089	0.233	0.089	0.233	0.040	0.081
BIOCARTA_GLYCOLYSIS_PATHWAY	3	0.89	0.840	1.34	1.261	0.087	0.159	0.087	0.159	0.044	0.082
BIOCARTA_KREB_PATHWAY	8	− 0.73	− 0.694	− 1.35	− 1.344	0.189	0.167	0.189	0.167	0.099	0.081

The significant glycolysis-related gene sets were highlighted in boldface when |NES|>1, and nominal p value < 0.1 and false discovery rate (FDR) q-value < 0.1

ISSN: 1479-7364