From: The role of m6A methylation in osteosarcoma biological processes and its potential clinical value
m6A regulators | Function | Target | Upstream | Role in | Biological function | Mechanism | Vitro/vivo | References |
---|---|---|---|---|---|---|---|---|
METTL3 | Writers | ATAD2 | – | Oncogene | Promotes cell proliferation, invasion and migration; Inhibits apoptosis | – | Vitro | [51] |
METTL3 | Writers | LEF1 | – | Oncogene | Promotes cell proliferation, invasion, migration and tumor growth | Activation of the wnt/β-catenin signaling pathway | Vitro and Vivo | [52] |
METTL3 | Writers | DRG1 | – | Oncogene | Promotes cell migration and colony formation; Inhibits apoptosis | – | Vitro | [53] |
METTL3 | Writers | TRIM7 | – | Oncogene | Promotes cell invasion and migration; Unfavorable response to chemotherapy | – | Vitro and Vivo | [59] |
METTL14 | Writers | TRIM7 | – | Oncogene | Promotes cell invasion and migration; Unfavorable response to chemotherapy | – | Vitro and Vivo | [59] |
WTAP | Writers | HMBOX1 | – | Oncogene | Promotes cell proliferation, invasion and migration | Activation of the PI3K/AKT signaling pathway | Vitro and Vivo | [55] |
KIAA1429 | Writers | – | miR-143-3p | Oncogene | Promotes cell proliferation, invasion and migration, tumor growth; Unfavorable response to chemotherapy | Activation of the Notch signaling pathway | Vitro and Vivo | [56] |
ALKBH5 | Erasers | PVT1 | – | Oncogene | Promotes cell proliferation and tumor growth | – | Vitro and Vivo | [54] |
ALKBH5 | Erasers | YAP | – | Tumor suppressor | Suppresses cell proliferation, invasion and migration; Trigger cell apoptosis | Activation of pre-miR-181b-1/YAP signaling | Vitro and Vivo | [72] |
YTHDF2 | Readers | – | miR-766 circ_0001105 | Tumor suppressor | Suppresses cell proliferation, invasion and migration; Favorable response to chemotherapy | – | Vitro and Vivo | [57] |
YTHDF2 | Readers | TRIM7 | – | Oncogene | Promotes cell invasion and migration; Unfavorable response to chemotherapy | – | Vitro and Vivo | [59] |
ELAVL1 | Readers | DRG1 | – | Oncogene | Promotes cell migration and colony formation; Inhibits apoptosis | – | Vitro | [53] |