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Table 1 Role of m6A modulators in osteosarcoma

From: The role of m6A methylation in osteosarcoma biological processes and its potential clinical value

m6A regulators

Function

Target

Upstream

Role in

Biological function

Mechanism

Vitro/vivo

References

METTL3

Writers

ATAD2

–

Oncogene

Promotes cell proliferation, invasion and migration; Inhibits apoptosis

–

Vitro

[51]

METTL3

Writers

LEF1

–

Oncogene

Promotes cell proliferation, invasion, migration and tumor growth

Activation of the wnt/β-catenin signaling pathway

Vitro and Vivo

[52]

METTL3

Writers

DRG1

–

Oncogene

Promotes cell migration and colony formation; Inhibits apoptosis

–

Vitro

[53]

METTL3

Writers

TRIM7

–

Oncogene

Promotes cell invasion and migration; Unfavorable response to chemotherapy

–

Vitro and Vivo

[59]

METTL14

Writers

TRIM7

–

Oncogene

Promotes cell invasion and migration; Unfavorable response to chemotherapy

–

Vitro and Vivo

[59]

WTAP

Writers

HMBOX1

–

Oncogene

Promotes cell proliferation, invasion and migration

Activation of the PI3K/AKT signaling pathway

Vitro and Vivo

[55]

KIAA1429

Writers

–

miR-143-3p

Oncogene

Promotes cell proliferation, invasion and migration, tumor growth; Unfavorable response to chemotherapy

Activation of the Notch signaling pathway

Vitro and Vivo

[56]

ALKBH5

Erasers

PVT1

–

Oncogene

Promotes cell proliferation and tumor growth

–

Vitro and Vivo

[54]

ALKBH5

Erasers

YAP

–

Tumor suppressor

Suppresses cell proliferation, invasion and migration; Trigger cell apoptosis

Activation of pre-miR-181b-1/YAP signaling

Vitro and Vivo

[72]

YTHDF2

Readers

–

miR-766

circ_0001105

Tumor suppressor

Suppresses cell proliferation, invasion and migration; Favorable response to chemotherapy

–

Vitro and Vivo

[57]

YTHDF2

Readers

TRIM7

–

Oncogene

Promotes cell invasion and migration; Unfavorable response to chemotherapy

–

Vitro and Vivo

[59]

ELAVL1

Readers

DRG1

–

Oncogene

Promotes cell migration and colony formation; Inhibits apoptosis

–

Vitro

[53]