Fig. 1

Mutation patterns and expression level of 26 RNA modification writers. A The top 20 mutated genes in 118 of 353 samples in TCGA-STAD dataset. Eight types of mutations were presented, including missense, nonsense, splice site mutation, in-frame deletions, frame-shift deletions or insertions, and different combinations of multiple genetic mutations (multi-hit). B Kaplan–Meier survival curve of mutant group and wild-type (WT) group. Log-rank test was performed. C Enriched pathways of hallmark gene set in mutant group and WT group. The dot size represents the count numbers of genes. D CNV distribution of 26 RNA modification writers. Red, green and blue represent gain of copy number, loss of copy number and no CNV, respectively. E Comparison of the expression level of 26 writers between cancer samples and normal samples grouped by m⁶A, m¹A, APA and A-I. Student’s t test was performed. F The expression level of 26 writers among gain of copy number (amplification), loss of copy number (deletion) and normal samples. Kruskal–Wallis test was performed. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns no significance