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Fig. 3 | Human Genomics

Fig. 3

From: Cross talk between RNA modification writers and tumor development as a basis for guiding personalized therapy of gastric cancer

Fig. 3

Construction of a signature of RNA modification writers. A Unsupervised consensus clustering of 194 RNA modification genes in GSE62254 dataset, and the comparison of two kinds of clustering. B, C WM score of different RNA modification patterns, cluster 1 and cluster 2 (B), cluster A and cluster B (C). Wilcoxon test was performed. D Kaplan–Meier survival curve of high-WM score and low-WM score groups in GSE62254 dataset. Log-rank test was performed. E ROC analysis of 1 year, 3 years and 5 years for WM score effectiveness in GSE62254 dataset. F Kaplan–Meier survival curve of high-WM score and low-WM score groups in TCGA-STAD dataset. Log-rank test was performed. G ROC analysis of 1 year, 3 years and 5 years for WM score effectiveness in TCGA-STAD dataset. (H-I) Multivariate Cox regression analysis of WM score, T stage, N stage, M stage, stage, age and gender in GSE62254 (H) and TCGA-STAD (I) dataset. Log-rank test was performed. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Human Genomics

ISSN: 1479-7364