Table 1 Medical indications

1. Genetic abnormality

2. Chromosomal abnormality

3. Mitochondrial abnormality

…that will manifest as a…

1. Serious physical or mental disability

2. Serious illness

3. Serious medical condition

1. Serious genetic abnormality

2. Serious genetic disease

3. Serious genetic condition

…that is associated with a known clinical deficit

1. Genetic mutation

2. Chromosomal abnormality

…that may result in the birth of a child with a serious genetic disease