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Table 1 Top 10 most significant BMI-associated SNPs related to m6A methylation

From: RNA modification-related variants in genomic loci associated with body mass index

SNP

Chromosome

Position

Gene

Gene type

Gene region

Effect allele

Other allele

Frequency

beta

se

P value

Confidence level

Modification function

rs6713978

2

24,897,982

ADCY3

Protein coding

intron

T

C

0.5593

−0.0319

0.002

6.40E−60

m6A-Label-seq: (High)

Functional Loss

rs13410999

2

24,875,070

ADCY3

Protein coding

intron

T

C

0.5548

−0.0316

0.002

8.20E−59

m6A-Label-seq: (High)

Functional Loss

rs12716973

16

29,926,333

KCTD13-DT

lncRNA

exon

A

G

0.5435

0.0231

0.002

8.90E−32

Prediction: (Low)

Functional Gain

rs8024

1

201,876,446

IPO9

Protein coding

3’-UTR

A

C

0.337

0.0237

0.0021

8.00E−31

miCLIP: (High)

Functional Loss

rs7250850

19

47,082,263

ZC3H4

Protein coding

CDS

C

G

0.7006

0.024

0.0022

1.50E−28

Prediction: (Low)

Functional Gain

rs1057233

11

47,354,898

SPI1

Protein coding

3’-UTR

A

G

0.6743

−0.0222

0.0021

4.10E−26

MeRIP-seq: (Medium)

Functional Loss

rs4146689

10

21,987,890

DNAJC1

Protein coding

intron

A

C

0.2778

0.0208

0.0022

5.30E−21

m6A-Label-seq: (High)

Functional Loss

rs4077410

16

29,986,877

TAOK2

Protein coding

CDS

A

G

0.4751

−0.0183

0.002

8.00E−21

MeRIP-seq: (Medium)

Functional Loss

rs2979247

8

9,031,438

ERI1

Protein coding

3’-UTR

A

G

0.5807

−0.0185

0.002

2.00E−20

Prediction: (Low)

Functional Loss

rs13642

11

30,410,661

MPPED2

Protein coding

3’-UTR

A

T

0.6373

0.0183

0.002

2.30E−19

Prediction: (Low)

Functional Gain