Fig. 1

ACE2 protein domains, coding missense variants, and full-length three-dimensional structure. A A schematic diagram displaying the different domains of human ACE2 including the signal peptide domain (SP), peptidase domain and collectrin homology domain. Dark blue regions correspond to the residues interacting with SARS-CoV-2 S protein. Residues labeled in red correspond to the 7N-glycosylation sites in ACE2. The studied coding variants are labeled in black and distributed based on their domain. B 3D structure of ACE2 protein along with its functional domains. Twenty-seven positions are only shown where 2 variants are available in Leu731 position. Signal peptide (pink), peptidase domain (gray), collectrin domain (orange), transmembrane domain (cyan), and cytoplasmic domain (purple) are shown in cartoon representation and amino acids are shown in stick representation