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Fig. 3 | Human Genomics

Fig. 3

From: rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms

Fig. 3

Expression of endogenous CD28 splicing isoforms is regulated by rs2013278. a Endogenous expression levels of CD28 in various human cell lines. b Endogenous expression levels of CD28 splicing isoforms in Jurkat T cells. *: non-specific peak. c Exon–intron structure of each CD28 splicing isoform. d Endogenous expression levels of CD28i and CD28Δex2 were relatively decreased in the risk allele knock-in version of Jurkat T cells generated by genome editing using CRISPR/Cas9 compared with expression levels in the non-risk allele cells

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