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Table 1 DKD GWAS sample characteristics

From: Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis

 

Control

Case

P value

(n = 7982)

(n = 5141)

Characteristics

Age (years)

73.8 ± 6.7

76.3 ± 5.6

2.20E−16

Women (%)

37.8

37.4

0.57

Diabetes duration (years)

14.2 ± 3.4

12.5 ± 5.4

2.20E−16

BMI

31.8 ± 5.9

32.6 ± 5.9

1.10E−14

HbA1c

6.7 ± 1.2

6.9 ± 1.4

3.86E−10

Biomarkers*

eGFR (mL/min/1.73 m2)

83.8 ± 10

63.8 ± 18

2.20E−16

Serum creatinine (mg/dl)

0.79 ± 015

1.1 ± 0.6

2.20E−16

Spot urinary creatinine (mg/dl)

113 ± 69

118 ± 73

2.98E−05

Urinary albumin (mg/l)

14.7 (10–1160)

24 (12–6747)

2.20E−16

Urinary sodium (mmol/l)

85 ± 45

78 ± 41

2.20E−16

Urinary potassium (mmol/l)

66.5 ± 33

63 ± 31

6.55E−11

  1. A total of 13,123 individuals with T2D were included in the analysis
  2. Characteristics and biomarkers are reported as the mean ± SD except for women (percentage) and urinary albumin (median and IQR)
  3. *Reported biomarkers values were collected at the first assessment visit to the UKBB for all study participants and before the DKD diagnosis in 84.5% of cases