Table 2 Genome-wide significant associations with eGFR, DKD, and DKD meta-analysis
P value | OR (95% CI) | Beta (95% CI) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | CHR | BP | Gene | A1 | A2 | MAF | DKD | eGFR (T2D) | eGFR (non-diabetic) | DKD Meta-analysis | DKD | DKD Meta-analysis | eGFR (T2D) | eGFR (non-diabetic) |
rs12917707 | 16 | 20,367,690 | UMOD | T | G | 0.18 | 1.17E−09 | 1.31E−15 | 1.54E−72 | 4.45E−08 | 0.80 (0.75, 0.86) | 0.8566 (0.81, 0.9) | 1.22 (0.9, 1.5) | 0.77 (0.7, 0.84) |
rs13333226 | 16 | 20,365,654 | UMOD | G | A | 0.19 | 3.27E−09 | 7.29E−15 | 8.96E−73 | NS | 0.81 (0.75, 0.87) | – | 1.18 (0.88, 1.47) | 0.77 (0.7, 0.84) |
rs4293393 | 16 | 20,364,588 | UMOD | G | A | 0.18 | 5.15E−09 | 1.71E−14 | 3.96E−73 | NS | 0.81 (0.76, 0.87) | – | 1.16 (0.86, 1.45) | 0.77 (0.7, 0.84) |
rs7185940 | 16 | 20,410,488 | PDILT | A | G | 0.28 | 5.36E−08 | 1.79E−12 | 1.45E−33 | NS | 0.84 (0.8, 0.9) | – | 0.92 (0.66, 1.71) | 0.44 (0.38, 0.5) |
rs7192797 | 16 | 20,411,763 | PDILT | A | G | 0.28 | 7.66E−08 | 4.58E−12 | 1.10E−33 | NS | 0.85 (0.8, 0.9) | – | 0.9 (0.64, 1.1) | 0.44 (0.38, 0.5) |
rs9926580 | 16 | 20,410,547 | PDILT | T | C | 0.28 | 6.61E−08 | 7.68E−12 | 3.86E−34 | NS | 0.85 (0.8, 0.9) | – | 0.89 (0.63, 1.1) | 0.45 (0.39, 0.5) |
rs11864909 | 16 | 20,400,839 | PDILT | T | C | 0.29 | NS | 1.35E−13 | 6.12E−45 | NS | – | – | 0.95 (0.7, 1.2) | 0.51 (0.45, 0.47) |
rs35208507 | 16 | 20,388,929 | PDILT | G | A | 0.31 | NS | 2.65E−12 | 5.26E−40 | NS | – | – | 0.88 (0.63, 1.13) | 0.88 (0.41, 0.52) |
rs4321205 | 16 | 20,375,536 | PDILT | T | C | 0.38 | NS | 8.23E−11 | 1.65E−30 | NS | – | – | 0.78 (0.54, 1) | 0.39 (0.33, 0.44) |
rs7805747 | 7 | 151,407,801 | PRKAG2 | A | G | 0.27 | NS | 2.79E−10 | 5.07E−72 | NS | – | – | − 0.83 (− 1.09, − 0.57) | − 0.66 (− 0.72, − 0.61) |
rs72763500 | 1 | 236,116,561 | NID1 | C | T | NS | NS | NS | 2.58E−08 | – | 0.7933 (0.73, 0.85) | – | – | |