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Fig. 6 | Human Genomics

Fig. 6

From: CRISPR-Cas9-mediated functional dissection of the foxc1 genomic region in zebrafish identifies critical conserved cis-regulatory elements

Fig. 6

foxc1a∆CED1−3 mutant embryos display defects in the developing superficial choroidal vasculature. A–C’ Three-dimensional maximum intensity projection images of the ocular vasculature in live control (A–C) or foxc1a∆CED1−3 homozygous (A’–C’) embryos carrying fli1a:EGFP transgene at 3-, 5- and 8-dpf. Mutant embryos show abnormal development of the dorsal and nasal radial vessels (orange arrowheads in A’–C’), enlarged and deformed superficial annular vessel (orange arrows) and a highly disorganized vasculogenesis in the ventral part of the eye with no visible ventral radial vessel at 5- and 8-dpf (orange asterisks). DRV (dorsal radial), NRV (nasal radial), SAV (superficial annular), and VRV (ventral radial) blood vessels are indicated

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Human Genomics

ISSN: 1479-7364