Fig. 1
From: Differential upregulation of AU-rich element-containing mRNAs in COVID-19
ARE-containing mRNAs are preferentially upregulated in virus-infected cell lines. A Fractions of ARE-containing mRNAs within the overexpressed and under-expressed groups of mRNAs in virus-infected cells. Virus and cell lines are indicated, ACE2 depicts cells expressing the receptor. MOI (Multiplicity of infection). P value for difference in population proportion depicted as ****(P < 0.0001). B Log2 Fold Change of uninfected control of ARE- and non-ARE mRNA levels are displayed. Significantly differentially expressed mRNA (Padj < 0.05) were split into those that contain AREs and those that do not (non-ARE) and displayed as a dot plot. Medians with interquartile ranges are displayed. The types of cell lines and infecting viruses are depicted. Statistical significance was determined by Mann–Whitney t test in Graph prism and P value displayed in graph ****(P < 0.0001). C The difference between medians of the Log2 Fold Change of ARE-mRNA and non-ARE mRNA in the indicated infected cell lines are displayed. D Volcano plots, Log2 Fold Change against -Log10 of adjusted P value of differentially expressed ARE-mRNAs in selected types of cells lines and infecting viruses. The dots of the 20 most significantly differentially expressed mRNAs are colored in red and their names are depicted