Fig. 5
From: Differential upregulation of AU-rich element-containing mRNAs in COVID-19
Analysis and functional clustering of upregulated ARE-mRNAs that are preferentially upregulated in the mild forms of COVID-19. A Left panel, Venn diagram of ARE-mRNAs that are upregulated in in blood sample of patients with four levels of disease severity OXY0, OXY1, TUBE early and TUBE late. Left panel, same as right panel but with mRNAs that lack AREs. B Log2 Fold Change of ARE and non-ARE mRNA levels in patients with no need of oxygen (OXY0) versus intubated patients (TUBE). Significantly differentially expressed mRNA (Padj < 0.05) were split into those that contain AREs and those that do not (non-ARE) and displayed as a dot plot. Medians with interquartile ranges are displayed and P value displayed in graph ****(P < 0.0001). C K-means clustering of the Log2 Fold Change values of the 849 mRNAs that were upregulated in OXY0, OXY1, TUBE early and TUBE late. The values were Johnson transformed with column scaling and clustered in JMP. D Cluster 3 from B was subjected to functional clustering in string and resulted in a functional cluster of 81 genes with highest significance