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Table 1 Comparison of laboratory parameters between deceased and recovered patients infected with COVID-19

From: Increased risk of COVID-19 mortality rate in IFITM3 rs6598045 G allele carriers infected by SARS-CoV-2 delta variant

Variables

Deceased patients (n = 1149)

Recovered patients (n = 1342)

P-value

Mean age ± SD

59.3 ± 10.9

51.0 ± 13.0

< 0.001*

Gender (male/female)

611/538 (53.2/46.8%)

697/645 (51.9/48.1%)

0.537

ALT, IU/L (mean ± SD) (Reference range: 5–40)

44.5 ± 23.9

33.2 ± 24.3

< 0.001*

AST, IU/L (mean ± SD) (Reference range: 5–40)

36.9 ± 13.0

31.3 ± 15.7

< 0.001*

ALP, IU/L (mean ± SD) (Reference range: up to 306)

201.9 ± 66.3

171.0 ± 90.6

< 0.001*

Cholesterol, mg/dL (mean ± SD) (Reference range: 50–200)

116.6 ± 38.9

121.8 ± 36.3

< 0.001*

TG, mg/dL (mean ± SD) (Reference range: 60–165)

116.6 ± 41.7

131.5 ± 61.5

< 0.001*

LDL, mg/dL (mean ± SD) (Reference range: up to 150)

70.2 ± 35.6

107.1 ± 49.3

< 0.001*

HDL, mg/dL (mean ± SD) (Reference range: > 40)

30.6 ± 10.9

34.4 ± 11.6

< 0.001*

WBC, 109/L (mean ± SD) (Reference range: 4000–10,000)

7544.4 ± 2663.4

7717.4 ± 2897.6

0.347

CRP, mg/L (mean ± SD) (Reference range: < 10 mg/L Negative)

67.3 ± 21.4

56.9 ± 20.9

< 0.001*

ESR, mm/1st h (mean ± SD) (Reference range: 0–15)

54.5 ± 15.6

46.5 ± 15.3

< 0.001*

FBS, mg/dL (mean ± SD) (Reference range: 70–100)

110.7 ± 42.9

105.6 ± 41.3

< 0.001*

Platelets × 1000/cumm (mean ± SD) (Reference range: 140,000–400,000)

186 ± 76

185 ± 65

0.206

Uric acid, mg/dL (mean ± SD) (Reference range: 3.6–6.8)

3.9 ± 1.2

5.6 ± 1.4

< 0.001*

Creatinine, mg/dL (mean ± SD) (Reference range: 0.6–1.4)

1.2 ± 0.3

0.7 ± 0.2

< 0.001*

T3, ng/dL (mean ± SD) (Reference range: 2.3–4.2)

3.1 ± 1.2

2.5 ± 0.8

0.061

T4, mcg/dL (mean ± SD) (Reference range: 5.6–13.7)

8.9 ± 4.6

8.3 ± 3.3

0.091

TSH, mu/L (mean ± SD) (Reference range: 0.4–4.5)

3.5 ± 1.4

3.3 ± 1.2

0.384

25-hydroxy vitamin D, ng/mL (mean ± SD) (Normal range: 21–150)

25.3 ± 10.1

35.9 ± 13.4

< 0.001*

SARS-CoV-2 variants

  

< 0.001*

 Alpha

396 (48.1%)

427 (51.9%)

 

 Delta

664 (75.3%)

218 (24.7%)

 

 Omicron BA.5

89 (11.2%)

697 (88.8%)

 

IFITM3 rs6598045

  

< 0.001*

 AA

190 (17.5%)

897 (82.5%)

 

 AG

508 (60.6%)

330 (39.4%)

 

 GG

451 (79.7%)

115 (20.3%)

 
  1. COVID-19 coronavirus disease 2019, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, TG triglyceride, LDL low density lipoprotein, HDL high density lipoprotein, WBC white blood cells, CRP C-reactive protein, ESR erythrocyte sedimentation rate, FBS fasting blood glucose, T3 triiodothyronine, T4 thyroxine, TSH thyroid-stimulating hormone, SD standard deviation, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, IFITM3 interferon-induced transmembrane protein 3.
  2. *Statistically significant (< 0.05)
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Human Genomics

ISSN: 1479-7364