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Table 1 Demographics, clinical characteristics, and family history of patients

From: Whole-exome sequencing of BRCA-negative breast cancer patients and case–control analyses identify variants associated with breast cancer susceptibility

Patient characteristics

Number (%)

Total number of patients

290 (100.0)

Race/ethnicity

Chinese

201 (69.3)

Malay

19 (6.6)

Indian

17 (5.9)

Caucasian

4 (1.4)

Filipino

4 (1.4)

Indonesian

3 (1.0)

Vietnamese

3 (1.0)

Arab

2 (0.7)

Bengali

1 (0.3)

Burmese

1 (0.3)

Gujarati

1 (0.3)

Tamil

1 (0.3)

Others

30 (10.3)

Not reported

3 (1.0)

Age at breast cancer diagnosis

Median

37.0 yrs

Range

19–75 yrs

 ≤ 40

225 (77.6)

 ≥ 41

65 (22.4)

Family history of breast cancer (n = 138)

At least first-degree

78 (26.9)

At least second-degree

43 (14.8)

At least third-degree

16 (5.5)

Unspecified

1 (0.3)

Family history of other cancers (n = 48)

At least first-degree

20 (6.9)

At least second-degree

28 (9.7)

Histology

Ductal carcinoma in situ (DCIS)

14 (4.8)

Infiltrating ductal carcinoma (IDC)

180 (62.1)

Infiltrating lobular carcinoma (ILC)

7 (2.4)

Mucinous carcinoma

9 (3.1)

Medullary carcinoma

2 (0.7)

Encapsulated papillary carcinoma

1 (0.3)

Tubulolobular carcinoma

1 (0.3)

DCIS + Lobular carcinoma in situ

1 (0.3)

DCIS + IDC + Mucinous

2 (0.7)

IDC + ILC

5 (1.7)

IDC + Invasive micropapillary carcinoma

1 (0.3)

IDC + Medullary

1 (0.3)

Subtype not defineda

66 (22.8)

Hormone and HER2 status

ER

 

 Positive

182 (62.8)

 Negative

68 (23.4)

 Not tested/unknowna

40 (13.8)

PR

 

 Positive

158 (54.5)

 Negative

90 (31)

 Not tested/unknowna

42 (14.5)

HER2

 

 Positive

77 (26.6)

 Negative

150 (51.7)

 Not tested/unknown/equivocala

63 (21.7)

  1. aClinical information for some patients was unavailable from one of the sites of this study due to the Institutional Review Board (IRB) approval obtained