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Table 2 IL10 gene polymorphisms association with COVID-19 mortality adjusted by SARS- CoV-2 variants

From: Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

IL10 rs1800871

Groups

Model

Genotype

Recovered patients

Deceased patients

OR (95% CI)

P-value

AIC

BIC

Allele

T

2281 (66.0%)

1585 (55.0%)

C

1187 (34.0%)

1315 (45.0%)

Codominant

T/T

716 (41.2%)

444 (30.6%)

1.00

 < 0.0001*

3927.2

3957.6

C/T

849 (49.0%)

697 (48.1%)

1.78 (1.50–2.12)

C/C

169 (9.8%)

309 (21.3%)

3.59 (2.82–4.56)

Dominant

T/T

716 (41.2%)

444 (30.6%)

1.00

 < 0.0001*

3963.5

3987.7

C/T- C/C

1018 (58.8%)

1006 (69.4%)

2.10 (1.79–2.48)

Recessive

T/T-C/T

1565 (90.2%)

1141 (78.7%)

1.00

 < 0.0001*

3970.1

3994.3

C/C

169 (9.8%)

309 (21.3%)

2.53 (2.04–3.13)

Overdominant

T/T-C/C

885 (51.0%)

753 (51.9%)

1.00

0.023

4040.6

4064.8

C/T

849 (49.0%)

697 (48.1%)

1.19 (1.02–1.38)

Minor allele frequency (C)

0.34

0.45

IL10 rs1800872

      

Allele

G

2290 (66.0%)

1753 (60.0%)

T

1178 (34.0%)

1147 (40.0%)

Codominant

G/G

703 (40.5%)

572 (39.5%)

1.00

 < 0.0001*

3948.0

3978.3

G/T

884 (51.0%)

609 (42.0%)

1.25 (1. 06–1.48)

T/T

147 (8.5%)

269 (18.6%)

3.39 (2.65–4.35)

Dominant

G/G

703 (40.5%)

572 (39.5%)

1.00

 < 0.0001*

4014.9

4039.1

G/T-T/T

1031 (59.5%)

878 (60.5%)

1.56 (1.33–1.83)

Recessive

G/G-G/T

1587 (91.5%)

1181 (81.5%)

1.00

 < 0.0001*

3953.0

3977.2

T/T

147 (8.5%)

269 (18.6%)

2.99 (2.38–3.75)

Overdominant

G/G-T/T

850 (49.0%)

841 (58.0%)

1.00

0.21

4044.2

4068.45

G/T

884 (51.0%)

609 (42.0%)

0.91 (0.78–1.06)

Minor allele frequency (T)

0.34

0.40

IL10 rs1800896

      

Allele

A

2530 (73.0%)

1755 (61.0%)

G

938 (27.0%)

1145 (39.0%)

Codominant

A/A

912 (52.6%)

531 (36.6%)

1.00

 < 0.0001*

3954.1

3984.4

A/G

706 (40.7%)

693 (47.8%)

1.95 (1. 66–2.29)

G/G

116 (6.7%)

226 (15.6%)

2.65 (2.04–3.45)

Dominant

A/A A/G-G/G

912 (52.6%)

531 (36.6%)

1.00

 < 0.0001*

3957.5

3981.8

822 (47.4%)

919 (63.4%)

2.07 (1.78–2.42)

Recessive

A/A-A/G

1618 (93.3%)

1224 (84.4%)

1.00

 < 0.0001*

4018.6

4042.8

G/G

116 (6.7%)

226 (15.6%)

1.91 (1.49–2.44)

Overdominant

A/A-G/G

1028 (59.3%)

757 (52.2%)

1.00

 < 0.0001*

4007.9

4032.2

A/G

706 (40.7%)

693 (47.8%)

1.61 (1.38–1.88)

Minor allele frequency (G)

0.27

0.39

  1. COVID-19 Coronavirus disease, OR Odds ratios, CI Confidence intervals, IL10 Interleukins 10, AIC Akaike information criterion, BIC Bayesian information criterion, OR Odds ratios, CI Confidence intervals; *Statistically significant (< 0.05)