Relationships between circulating metabolites and facial skin aging: a Mendelian randomization study

Table 2 Ranking of unsaturation-related metabolic biomarkers for the risk of skin aging using MR-BMA

Metabolite biomarkers	MR-base ID	Ranking by MIP	MIP	Average effect	p value
Degree of unsaturation	met-d-Unsaturation	1	0.654	0.056	0.009901
Ratio of polyunsaturated fatty acids to monounsaturated fatty acids	met-d-PUFA_by_MUFA	2	0.106	0.008	0.039604
Ratio of monounsaturated fatty acids to total fatty acids	met-d-MUFA_pct	3	0.093	− 0.006	0.039604
Ratio of polyunsaturated fatty acids to total fatty acids	met-d-PUFA_pct	4	0.088	0.007	0.09901
Ratio of docosahexaenoic acid to total fatty acids	met-d-DHA_pct	5	0.067	0.002	0.366337
Docosahexaenoic acid	met-d-DHA	6	0.025	− 0.001	0.930693
Ratio of omega-3 fatty acids to total fatty acids	met-d-Omega_3_pct	7	0.02	0.002	0.930693
Ratio of linoleic acid to total fatty acids	met-d-LA_pct	8	0.018	− 0.001	0.960396
Ratio of omega-6 fatty acids to total fatty acids	met-d-Omega_6_pct	9	0.017	0.001	0.970297
Ratio of omega-6 fatty acids to omega-3 fatty acids	met-d-Omega_6_by_Omega_3	10	0.016	0.001	0.950495
Linoleic acid	met-d-LA	11	0.013	− 0.002	0.980198
Monounsaturated fatty acids	met-d-MUFA	12	0.012	− 0.001	0.039604
Omega-6 fatty acids	met-d-Omega_6	13	0.011	0.001	0.980198
Omega-3 fatty acids	met-d-Omega_3	14	0.011	0	0.970297
Saturated fatty acids	met-d-SFA	15	0.008	0	0.990099
Polyunsaturated fatty acids	met-d-PUFA	16	0.007	0	0.990099
Ratio of saturated fatty acids to total fatty acids	met-d-SFA_pct	17	0.005	0	1

MIP marginal inclusion probability, MR Mendelian randomization, MR-BMA MR based on Bayesian model averaging, PUFA polyunsaturated fatty acids, MUFA monounsaturated fatty acids, DHA docosahexaenoic acid, LA linoleic acid, SFA saturated fatty acids

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