Fig. 4
From: In silico prioritisation of microRNA-associated common variants in multiple sclerosis
A Table showing the p values and odds ratio (OR) for the 6 independent 3′UTR independent SNPs. Among these, only 3 (highlighted in bold) meet 3 of the microRNA–target validation criteria (see Methods, Additional file 1: Table S9). Joint p values (from IMSGC’s discovery and replication processes) are available for the IMSGC independent (suggestive) SNPs, but not for those identified by FUMA, as these were not among the suggestive effects. For the latter group, we have showed the discovery p values and ORs. B LocusZoom plots showing regions around our other 2 functionally relevant SNPs (rs2587100 is in Fig. 3E). We have highlighted the 3′UTR SNPs in rs1059501 (CD27) and rs881640 (MMEL1). Our candidate SNP rs1059501 is independent from the IMSGC susceptibility/genome-wide SNPs (rs1800693, rs2364485, rs12832171) in that region and was ranked as strongly suggestive in the IMSGC stepwise regression. C Our candidate SNP rs881640 is independent from the IMSGC susceptibility/genome-wide SNP (chr1:2520527(hg37); rs6670198) in that region